Gene Review:
Parp1 - poly (ADP-ribose) polymerase 1
Rattus norvegicus
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 1, ADPRT 1, ARTD1, Adprt, NAD(+) ADP-ribosyltransferase 1, ...
- Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. Tanaka, S., Takehashi, M., Iida, S., Kitajima, T., Kamanaka, Y., Stedeford, T., Banasik, M., Ueda, K. J. Neurochem. (2005)
- Blockade of PARP activity attenuates poly(ADP-ribosyl)ation but offers only partial neuroprotection against NMDA-induced cell death in the rat retina. Goebel, D.J., Winkler, B.S. J. Neurochem. (2006)
- Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment. Suh, S.W., Aoyama, K., Matsumori, Y., Liu, J., Swanson, R.A. Diabetes (2005)
- 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion. Chatterjee, P.K., Chatterjee, B.E., Pedersen, H., Sivarajah, A., McDonald, M.C., Mota-Filipe, H., Brown, P.A., Stewart, K.N., Cuzzocrea, S., Threadgill, M.D., Thiemermann, C. Kidney Int. (2004)
- Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity. Zhang, Y., Rosenberg, P.A. Eur. J. Neurosci. (2004)
- Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury. Kendirci, M., Zsengellér, Z., Bivalacqua, T.J., Gur, S., Usta, M.F., Chen, M., Szabó, C., Hellstrom, W.J. J. Urol. (2005)
- Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus. Adamczyk, A., Jeśko, H., Strosznajder, R.P. Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. (2005)
- An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation. Schuman, E.M., Meffert, M.K., Schulman, H., Madison, D.V. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Prevention of bile acid-induced apoptosis by betaine in rat liver. Graf, D., Kurz, A.K., Reinehr, R., Fischer, R., Kircheis, G., Häussinger, D. Hepatology (2002)
- Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. Kruman, I.I., Culmsee, C., Chan, S.L., Kruman, Y., Guo, Z., Penix, L., Mattson, M.P. J. Neurosci. (2000)
- Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. Chiarugi, A. Br. J. Pharmacol. (2002)
- Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat. Besson, V.C., Zsengellér, Z., Plotkine, M., Szabó, C., Marchand-Verrecchia, C. Brain Res. (2005)
- Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage). Kim, S.C., Byun, S.H., Yang, C.H., Kim, C.Y., Kim, J.W., Kim, S.G. Toxicology (2004)
- Early molecular changes in irradiated aortic endothelium. Gajdusek, C., Onoda, K., London, S., Johnson, M., Morrison, R., Mayberg, M. J. Cell. Physiol. (2001)
- Ontogeny of poly(ADP-ribose) polymerase-1 in lung and developmental implications. Ertsey, R., Chapin, C.J., Kitterman, J.A., Scavo, L.M. Am. J. Respir. Cell Mol. Biol. (2004)
- Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery. Zhang, C., Yang, J., Jennings, L.K. Am. J. Physiol. Heart Circ. Physiol. (2004)
- Co-localization of poly(ADPR)polymerase 1 (PARP-1) poly(ADPR)polymerase 2 (PARP-2) and related proteins in rat testis nuclear matrix defined by chemical cross-linking. Tramontano, F., Di Meglio, S., Quesada, P. J. Cell. Biochem. (2005)
- Aging splenocyte and thymocyte apoptosis is associated with enhanced expression of p53, bax, and caspase-3. Kapasi, A.A., Singhal, P.C. Mol. Cell Biol. Res. Commun. (1999)
- Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors. Di Meglio, S., Tramontano, F., Cimmino, G., Jones, R., Quesada, P. Biochim. Biophys. Acta (2004)
- Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation. Prabhakaran, K., Li, L., Borowitz, J.L., Isom, G.E. Toxicol. Appl. Pharmacol. (2004)
- Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia. Tyagi, N., Ovechkin, A.V., Lominadze, D., Moshal, K.S., Tyagi, S.C. J. Cell. Biochem. (2006)
- Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in rat. Maione, S., Siniscalco, D., Galderisi, U., de Novellis, V., Uliano, R., Di Bernardo, G., Berrino, L., Cascino, A., Rossi, F. Neuroreport (2002)
- Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress. Du, L., Zhang, X., Han, Y.Y., Burke, N.A., Kochanek, P.M., Watkins, S.C., Graham, S.H., Carcillo, J.A., Szabó, C., Clark, R.S. J. Biol. Chem. (2003)
- Apoptotic cell death progression after photothrombotic focal cerebral ischaemia: effects of the lipophilic iron chelator 2,2'-dipyridyl. Van Hoecke, M., Prigent-Tessier, A., Bertrand, N., Prevotat, L., Marie, C., Beley, A. Eur. J. Neurosci. (2005)
- Transgenic expression of human FGF-1 protects against hypoxic-ischemic injury in perinatal brain by intervening at caspase-XIAP signaling cascades. Russell, J.C., Szuflita, N., Khatri, R., Laterra, J., Hossain, M.A. Neurobiol. Dis. (2006)
- Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Halmosi, R., Berente, Z., Osz, E., Toth, K., Literati-Nagy, P., Sumegi, B. Mol. Pharmacol. (2001)
- Poly(ADPribosyl)ation system in rat germinal cells at different stages of differentiation. Quesada, P., Atorino, L., Cardone, A., Ciarcia, G., Farina, B. Exp. Cell Res. (1996)
- Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells. Yunta, M., Rodríguez-Barbero, A., Arévalo, M.A., López-Novoa, J.M., Lazo, P.A. Kidney Int. (2003)