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Chemical Compound Review

Cosmegen     2-amino-4,6-dimethyl-3-oxo- N,N'-bis(7,11...

Synonyms: Dactinomicina, Dactinomycine, Dactinomycinum, Meractinomycin, Acto-D, ...
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Disease relevance of Cosmegen


Psychiatry related information on Cosmegen


High impact information on Cosmegen

  • Inhibition of mRNA transcription with actinomycin D shows that the epidermal antigen is certainly transcribed by the late gastrula stage (stage 12) [10].
  • Activation of RNA cap methylation is inhibited by aphidicolin, but not by actinomycin D, suggesting that this process is temporally coordinated with DNA replication, but independent of RNA transcription [11].
  • Enzyme induction is transiently sensitive to inhibition by actinomycin D, suggesting that increased concentrations of cAMP mediate the inducing effects of the hormones by enhancing the transcription of PA-mRNA sequences [12].
  • However, RNA polymerase B molecules remain associated with the chromosomal template even after an in vivo alpha-amanitin or actinomycin D treatment to inhibit RNA synthesis [13].
  • During a 30 min actinomycin D chase, most of the alpha- and beta-globin mRNA precursors and processing intermediates are converted to mRNA-sized RNA [14].

Chemical compound and disease context of Cosmegen


Biological context of Cosmegen

  • Analysis of heteroduplexes with 8.2 kb DNA suggested that actinomycin D could block the reverse transcription of most of the sequence in the genome RNA that appears as a leader in the 21S RNA [20].
  • One of these species, 8.8 kb long, is only made in the absence of actinomycin D, but it does not contain any self-complementary sequences, and therefore appears to be a complete transcript of the viral genome [20].
  • In the study described here, actinomycin D was used to examine the timing of the RNA synthetic events necessary for (1) neurite outgrowth and (2) development of the ionic dependence of the action potential [21].
  • The increase in the RNA levels of the proto-oncogenes was prevented in the presence of alpha-amanitin or actinomycin D [22].
  • Brief actinomycin D treatment of conjugating cells blocked M-element excision, providing evidence that transcription is important for efficient DNA rearrangement [23].

Anatomical context of Cosmegen


Associations of Cosmegen with other chemical compounds


Gene context of Cosmegen


Analytical, diagnostic and therapeutic context of Cosmegen


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