Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

MYH3 - myosin, heavy chain 3, skeletal muscle,...

Homo sapiens

Synonyms: HEMHC, MYHC-EMB, MYHSE1, Muscle embryonic myosin heavy chain, Myosin heavy chain 3, ...

Toydemir, R.M. et al., Hundley, A.F. et al., Dunn, J.R. et al.

Hundley, Yuan, Visco,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MYH3

Here we show that mutations in the embryonic myosin heavy chain (MYH3) gene cause Freeman-Sheldon syndrome (FSS), one of the most severe multiple congenital contracture (that is, arthrogryposis) syndromes, and nearly one-third of all cases of Sheldon-Hall syndrome (SHS), the most common distal arthrogryposis [1].
MYH3 was 10.9 times underexpressed in patients with pelvic organ prolapse compared to controls (P = .027) [2].

High impact information on MYH3

A transcript map of MRIII has been generated and contains 25 candidate BOA genes, four of which are the named genes MYH3, SCO1, x006 and MAGOH-LIKE [3].
OBJECTIVE: The purpose of this study was to compare gene expression of skeletal muscle heavy-chain polypeptide 3 (MYH3) and myosin binding protein H (MyBP-H) in the pubococcygeus muscle of patients with pelvic organ prolapse and controls [2].

Biological context of MYH3

FSS and SHS mutations affect different myosin residues, demonstrating that MYH3 genotype is predictive of phenotype [1].

References

Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Toydemir, R.M., Rutherford, A., Whitby, F.G., Jorde, L.B., Carey, J.C., Bamshad, M.J. Nat. Genet. (2006) [Pubmed]
Skeletal muscle heavy-chain polypeptide 3 and myosin binding protein H in the pubococcygeus muscle in patients with and without pelvic organ prolapse. Hundley, A.F., Yuan, L., Visco, A.G. Am. J. Obstet. Gynecol. (2006) [Pubmed]
Physical and transcript map of the minimally deleted region III on 17p implicated in the early development of Barrett's oesophageal adenocarcinoma. Dunn, J.R., Risk, J.M., Langan, J.E., Marlee, D., Ellis, A., Campbell, F., Watson, A.J., Field, J.K. Oncogene (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

MYH3	Bos taurus
MYH3	Canis lupus familiaris
MYH3	Macaca mulatta
Myh3	Mus musculus
MYH3	Pan troglodytes
Myh3	Rattus norvegicus
LOC100495065	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.