The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Contracture


Psychiatry related information on Contracture


High impact information on Contracture


Chemical compound and disease context of Contracture


Biological context of Contracture


Anatomical context of Contracture


Gene context of Contracture

  • UCMD, a severe disorder characterized by congenital muscle weakness, proximal joint contractures and marked distal joint hyperextensibility, has been considered a recessive condition, and homozygous or compound heterozygous mutations have been defined in COL6A2 and COL6A3 [27].
  • OBJECTIVE: To measure the levels of prostaglandin endoperoxide H synthase (PGHS) isozymes (or cyclooxygenase, COX) in vivo during the development of joint contractures secondary to immobilization in rats [28].
  • Different levels of COX-1 and COX-2 enzymes in synoviocytes and chondrocytes during joint contracture formation [28].
  • Patients with a proliferative active disease (n = 14) had a significantly higher TIMP-1 concentration (525 +/- 136 ng/ml) than patients (n = 8) with a contracture in the late involutional and residual phase (286 +/- 41 ng/ml; p < 0.05) [29].
  • We investigated the frequency of the 23 published MH linked RYR1 gene mutations in the Swiss MH population and compared our findings to the results of the in vitro contracture test (IVCT) [30].

Analytical, diagnostic and therapeutic context of Contracture


  1. Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy. Bione, S., Maestrini, E., Rivella, S., Mancini, M., Regis, S., Romeo, G., Toniolo, D. Nat. Genet. (1994) [Pubmed]
  2. Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice. Burkin, D.J., Wallace, G.Q., Nicol, K.J., Kaufman, D.J., Kaufman, S.J. J. Cell Biol. (2001) [Pubmed]
  3. Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia. Matherne, G.P., Linden, J., Byford, A.M., Gauthier, N.S., Headrick, J.P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B. Sung, S.S., Brassington, A.M., Krakowiak, P.A., Carey, J.C., Jorde, L.B., Bamshad, M. Am. J. Hum. Genet. (2003) [Pubmed]
  5. Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. Kang, J.X., Leaf, A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Merosin-deficient congenital muscular dystrophy with mental retardation and cerebellar cysts unlinked to the LAMA2, FCMD and MEB loci. Talim, B., Ferreiro, A., Cormand, B., Vignier, N., Oto, A., Göğüş, S., Cila, A., Lehesjoki, A.E., Pihko, H., Guicheney, P., Topaloğlu, H. Neuromuscul. Disord. (2000) [Pubmed]
  7. Visualization of silicone gel in human breast tissue using new infrared imaging spectroscopy. Kidder, L.H., Kalasinsky, V.F., Luke, J.L., Levin, I.W., Lewis, E.N. Nat. Med. (1997) [Pubmed]
  8. Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2. McCarthy, T.V., Healy, J.M., Heffron, J.J., Lehane, M., Deufel, T., Lehmann-Horn, F., Farrall, M., Johnson, K. Nature (1990) [Pubmed]
  9. The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Bridge, J.H., Smolley, J.R., Spitzer, K.W. Science (1990) [Pubmed]
  10. Potassium chloride versus voltage clamp contractures in ventricular muscle. Morad, M., Reeck, S., Rao, M. Science (1981) [Pubmed]
  11. Excitation-contraction coupling in skeletal muscle: blockade by high extracellular concentrations of calcium buffers. Barrett, N., Barrett, E.F. Science (1978) [Pubmed]
  12. Possible cyclic nucleotide regulation of calcium mediating myocardial contraction. Schwartz, A., Endman, M.L., Ezrailson, E.G., Lehotay, D.C., Leyey, G. Science (1977) [Pubmed]
  13. Beneficial effects of penicillamine treatment on hereditary avian muscular dystrophy. Chou, T., Hill, E.J., Bartle, E., Woolley, K., LeQuire, V., Olson, W., Roelofs, R., Park, J.H. J. Clin. Invest. (1975) [Pubmed]
  14. Anaesthetic-induced increase in ionised calcium in blood mononuclear cells from malignant hyperthermia patients. Klip, A., Britt, B.A., Elliott, M.E., Pegg, W., Frodis, W., Scott, E. Lancet (1987) [Pubmed]
  15. Effects of amrinone on contraction and K+-induced contracture of normal and subacutely failed cat ventricular muscle. Gaide, M.S., Kimura, S., Lodge, N.J., Cameron, J.S., Kozlovskis, P.L., Myerburg, R.J., Bassett, A.L. Circulation (1986) [Pubmed]
  16. Importance of endogenous adenosine during ischemia and reperfusion in neonatal porcine hearts. Sommerschild, H.T., Grund, F., Offstad, J., Jynge, P., Ilebekk, A., Kirkebøen, K.A. Circulation (1997) [Pubmed]
  17. Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy. Girgenrath, M., Dominov, J.A., Kostek, C.A., Miller, J.B. J. Clin. Invest. (2004) [Pubmed]
  18. Effects of inosine on glycolysis and contracture during myocardial ischemia. Lewandowski, E.D., Johnston, D.L., Roberts, R. Circ. Res. (1991) [Pubmed]
  19. The effects of isoproterenol and ouabain on oxygen consumption, lactate production, and the activation of phosphorylase in coronary artery smooth muscle. Paul, R.J. Circ. Res. (1983) [Pubmed]
  20. Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts. Owen, P., Dennis, S., Opie, L.H. Circ. Res. (1990) [Pubmed]
  21. A diastrophic dysplasia sulfate transporter (SLC26A2) mutant mouse: morphological and biochemical characterization of the resulting chondrodysplasia phenotype. Forlino, A., Piazza, R., Tiveron, C., Della Torre, S., Tatangelo, L., Bonafè, L., Gualeni, B., Romano, A., Pecora, F., Superti-Furga, A., Cetta, G., Rossi, A. Hum. Mol. Genet. (2005) [Pubmed]
  22. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Muchir, A., Bonne, G., van der Kooi, A.J., van Meegen, M., Baas, F., Bolhuis, P.A., de Visser, M., Schwartz, K. Hum. Mol. Genet. (2000) [Pubmed]
  23. Stimulation of muscarinic receptors raises free intracellular Ca2+ concentration in rat ventricular myocytes. Korth, M., Sharma, V.K., Sheu, S.S. Circ. Res. (1988) [Pubmed]
  24. Myocyte adaptation to chronic hypoxia and development of tolerance to subsequent acute severe hypoxia. Silverman, H.S., Wei, S., Haigney, M.C., Ocampo, C.J., Stern, M.D. Circ. Res. (1997) [Pubmed]
  25. A gene for a severe lethal form of X-linked arthrogryposis (X-linked infantile spinal muscular atrophy) maps to human chromosome Xp11.3-q11.2. Kobayashi, H., Baumbach, L., Matise, T.C., Schiavi, A., Greenberg, F., Hoffman, E.P. Hum. Mol. Genet. (1995) [Pubmed]
  26. Increase in radioresponse of murine tumors by treatment with indomethacin. Furuta, Y., Hunter, N., Barkley, T., Hall, E., Milas, L. Cancer Res. (1988) [Pubmed]
  27. Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy. Baker, N.L., Mörgelin, M., Peat, R., Goemans, N., North, K.N., Bateman, J.F., Lamandé, S.R. Hum. Mol. Genet. (2005) [Pubmed]
  28. Different levels of COX-1 and COX-2 enzymes in synoviocytes and chondrocytes during joint contracture formation. Trudel, G., Desaulniers, N., Uhthoff, H.K., Laneuville, O. J. Rheumatol. (2001) [Pubmed]
  29. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytren's disease. Ulrich, D., Hrynyschyn, K., Pallua, N. Plast. Reconstr. Surg. (2003) [Pubmed]
  30. Genotype-phenotype comparison of the Swiss malignant hyperthermia population. Girard, T., Urwyler, A., Censier, K., Mueller, C.R., Zorzato, F., Treves, S. Hum. Mutat. (2001) [Pubmed]
  31. Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. Bertocchini, F., Ovitt, C.E., Conti, A., Barone, V., Schöler, H.R., Bottinelli, R., Reggiani, C., Sorrentino, V. EMBO J. (1997) [Pubmed]
  32. Role of endothelin-A receptors in ischemic contracture and reperfusion injury. Brunner, F., Opie, L.H. Circulation (1998) [Pubmed]
  33. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Steenbergen, C., Murphy, E., Watts, J.A., London, R.E. Circ. Res. (1990) [Pubmed]
  34. Modification of caffeine-induced injury in Ca2+-free perfused rat hearts. Relationship to the calcium paradox. Vander Heide, R.S., Altschuld, R.A., Lamka, K.G., Ganote, C.E. Am. J. Pathol. (1986) [Pubmed]
WikiGenes - Universities