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Gene Review:

BP13 - Blood pressure QTL 13

Homo sapiens

Bartsevich, V.V. et al., Urakami, S. et al., Heber, M.E. et al.

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Disease relevance of BP13

Using a newly developed selection scheme, we have isolated BP13, a random photosynthesis-deficient mutant strain of the cyanobacterium, Synechocystis 6803 [1].
Day/night variation was significantly reduced in the patients with chronic renal failure (BP 13/7 +/- 8/6 mmHg, HR 5 +/- 4) compared with a control population (BP 36/28 +/- 10/5 mmHg, HR 19 +/- 6) [2].

High impact information on BP13

We determined that in the BP13 strain, a single nucleotide change had resulted in the replacement of an alanine by an aspartic acid residue in MntA, a soluble protein containing ATP binding motifs [1].
MATERIALS AND METHODS: Chemically [N-ethyl-N-hydroxyethylnitrosamine (EHEN)]-induced non-Eker rat RC lines (designated as BP13 and BP36B) were subjected to PCR-single strand conformation polymorphism (PCR-SSCP) analysis using specific primers covering entire exons of Tsc2 gene (41 coding exons and one non-coding exon) [3].

References

Molecular identification of an ABC transporter complex for manganese: analysis of a cyanobacterial mutant strain impaired in the photosynthetic oxygen evolution process. Bartsevich, V.V., Pakrasi, H.B. EMBO J. (1995) [Pubmed]
Baroreceptor, not left ventricular, dysfunction is the cause of hemodialysis hypotension. Heber, M.E., Lahiri, A., Thompson, D., Raftery, E.B. Clin. Nephrol. (1989) [Pubmed]
Somatic mutation of the tuberous sclerosis (Tsc2) tumor suppressor gene in chemically induced rat renal carcinoma cell. Urakami, S., Tokuzen, R., Tsuda, H., Igawa, M., Hino, O. J. Urol. (1997) [Pubmed]

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