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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Population Control

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Disease relevance of Population Control


Psychiatry related information on Population Control


High impact information on Population Control

  • The relationship between GTase and G(0) was found to be positive and linear in the control population and negative and linear in the RA population [11].
  • Allele frequencies were calculated for the 2 MS patient groups and compared with those found in a control population from the same geographical location and of similar ethnic background [12].
  • Within the control population, 18.1% of them had antibodies that reacted with the E4 protein, and 3.9% of them had antibodies that reacted with the E7 protein [13].
  • Furthermore, nonresponsive leukocytes from the control population converted to tumor antigen-responsive when incubated with sera from vasectomized LaI-positive men [14].
  • Of the patients positive for DRw2, 47% had the association A26 and Bw38 as compared with the control population association incidence of 21% (P less than 0.1) [15].

Chemical compound and disease context of Population Control


Biological context of Population Control


Anatomical context of Population Control


Associations of Population Control with chemical compounds

  • Examination of the human KCR1 sequence in patients with drug-induced cardiac repolarization defects revealed a sequence variation (the substitution of isoleucine 447 by valine, I447V) that occurs at a reduced frequency (1.1%) relative to a matched control population (7.0%), suggesting that I447V may be an allele for reduced aLQTS susceptibility [31].
  • This pattern of aggregation was clearly different from that occasionally caused by heparin in a control population [32].
  • Transduced colony-forming unit-granulocyte-macrophage (CFU-GM), assayed directly after the transduction procedure, were protected completely against 2 x 10(-8) mol/L MTX, a concentration that significantly reduced the CFU-GM detected in the control population [33].
  • In addition, elevation of serum cholesterol, noted in 20 patients (67%), was significant (P = .014) when compared with a control population [34].
  • Activity of ChAT and AChE, content of 5-HT, 5-HIAA, and DA, binding of 5-[3H]HT, and the turnover number for DA (ratio of HVA/DA) all decreased with increasing age in the non-HD control population [35].

Gene context of Population Control

  • Furthermore, we report that there was a significant difference in the observed numbers of SAA1 alleles between rheumatoid arthritis patients with AA-amyloidosis and the control population (chi 2(2) = 11.59, p = 0.003) with a higher frequency of gamma-allele in the AA-amyloid group (0.70 vs. 0.37) [36].
  • We evaluated a series of European CRC patients and population controls to clarify whether EXO1 variants may indeed predispose to familial CRC [37].
  • METHODS: We identified 274 HLA-DRB1*04-positive cases of RA and 271 HLA-DRB1*04-positive population controls [38].
  • METHODS: Association with CARD15 and OCTN was investigated in UK Caucasian patients with PsA (n = 472) and population controls (n = 594), using 5' allelic discrimination assays (TaqMan) [39].
  • RESULTS: The median urinary dextromethorphan/dextrorphan metabolic ratio (MR) indicated significantly lower CYP2D6 activity in the black American group (0.016) than in a white control population (0.0044; P =.0001) studied previously [40].

Analytical, diagnostic and therapeutic context of Population Control


  1. Young adults with head and neck cancer express increased susceptibility to mutagen-induced chromosome damage. Schantz, S.P., Hsu, T.C., Ainslie, N., Moser, R.P. JAMA (1989) [Pubmed]
  2. Decreased selenium levels in acute myocardial infarction. Kok, F.J., Hofman, A., Witteman, J.C., de Bruijn, A.M., Kruyssen, D.H., de Bruin, M., Valkenburg, H.A. JAMA (1989) [Pubmed]
  3. The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease. Dring, M.M., Goulding, C.A., Trimble, V.I., Keegan, D., Ryan, A.W., Brophy, K.M., Smyth, C.M., Keeling, P.W., O'Donoghue, D., O'Sullivan, M., O'Morain, C., Mahmud, N., Wikström, A.C., Kelleher, D., McManus, R. Gastroenterology (2006) [Pubmed]
  4. The frequency of lupus anticoagulant in systemic lupus erythematosus. A study of sixty consecutive patients by activated partial thromboplastin time, Russell viper venom time, and anticardiolipin antibody level. Petri, M., Rheinschmidt, M., Whiting-O'Keefe, Q., Hellmann, D., Corash, L. Ann. Intern. Med. (1987) [Pubmed]
  5. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Smirnova, I., Mann, N., Dols, A., Derkx, H.H., Hibberd, M.L., Levin, M., Beutler, B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease. Singleton, A.B., Smith, G., Gibson, A.M., Woodward, R., Perry, R.H., Ince, P.G., Edwardson, J.A., Morris, C.M. Hum. Mol. Genet. (1998) [Pubmed]
  7. Increased frequency of the tumor necrosis factor-alpha-308 A allele in adults with human immunodeficiency virus dementia. Quasney, M.W., Zhang, Q., Sargent, S., Mynatt, M., Glass, J., McArthur, J. Ann. Neurol. (2001) [Pubmed]
  8. High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes. Taylor, K.G., Wright, A.D., Carter, T.J., Valente, A.J., Betts, S.A., Matthews, K.A. Diabetologia (1981) [Pubmed]
  9. Selective effect of lithium on cognitive performance in man. Glue, P.W., Nutt, D.J., Cowen, P.J., Broadbent, D. Psychopharmacology (Berl.) (1987) [Pubmed]
  10. Detection of the fragile X syndrome protein for the evaluation of FMR1 intermediate alleles. Castellví-Bel, S., Fernández-Burriel, M., Rifé, M., Jiménez, D., Mallolas, J., Sánchez, A., Ramos, F., Milà, M. Hum. Genet. (2000) [Pubmed]
  11. Changes in normal glycosylation mechanisms in autoimmune rheumatic disease. Axford, J.S., Sumar, N., Alavi, A., Isenberg, D.A., Young, A., Bodman, K.B., Roitt, I.M. J. Clin. Invest. (1992) [Pubmed]
  12. Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region. Walter, M.A., Gibson, W.T., Ebers, G.C., Cox, D.W. J. Clin. Invest. (1991) [Pubmed]
  13. Antibodies against the human papillomavirus type 16 early proteins in human sera: correlation of anti-E7 reactivity with cervical cancer. Jochmus-Kudielka, I., Schneider, A., Braun, R., Kimmig, R., Koldovsky, U., Schneweis, K.E., Seedorf, K., Gissmann, L. J. Natl. Cancer Inst. (1989) [Pubmed]
  14. Immunity to tumor-associated antigens in vasectomized men. Anderson, D.J., Alexander, N.J., Fulgham, D.L., Vandenbark, A.A., Burger, D.R. J. Natl. Cancer Inst. (1982) [Pubmed]
  15. Association of HLA-DRw2 with autoimmune thrombocytopenic purpura. Karpatkin, S., Fotino, M., Gibofsky, A., Winchester, R.J. J. Clin. Invest. (1979) [Pubmed]
  16. Vitamin A and prostate cancer in elderly men: enhancement of risk. Kolonel, L.N., Hankin, J.H., Yoshizawa, C.N. Cancer Res. (1987) [Pubmed]
  17. Effect of a low fat diet on carbohydrate metabolism in patients with hypertension. Parillo, M., Coulston, A., Hollenbeck, C., Reaven, G. Hypertension (1988) [Pubmed]
  18. Use of candesartan cilexetil decreases proteinuria in renal transplant patients with chronic allograft dysfunction. Omoto, K., Tanabe, K., Tokumoto, T., Shimmura, H., Ishida, H., Toma, H. Transplantation (2003) [Pubmed]
  19. Serum pituitary and sex steroid hormone levels in the etiology of prostatic cancer--a population-based case-control study. Andersson, S.O., Adami, H.O., Bergström, R., Wide, L. Br. J. Cancer (1993) [Pubmed]
  20. Serum steroid hormone levels, sex hormone-binding globulin, and body mass index in the etiology of postmenopausal breast cancer. Lipworth, L., Adami, H.O., Trichopoulos, D., Carlström, K., Mantzoros, C. Epidemiology (Cambridge, Mass.) (1996) [Pubmed]
  21. Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy. Raynolds, M.V., Bristow, M.R., Bush, E.W., Abraham, W.T., Lowes, B.D., Zisman, L.S., Taft, C.S., Perryman, M.B. Lancet (1993) [Pubmed]
  22. Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group. Hateboer, N., v Dijk, M.A., Bogdanova, N., Coto, E., Saggar-Malik, A.K., San Millan, J.L., Torra, R., Breuning, M., Ravine, D. Lancet (1999) [Pubmed]
  23. Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells. Muschel, R.J., Zhang, H.B., McKenna, W.G. Cancer Res. (1993) [Pubmed]
  24. The pill, parity, and rheumatoid arthritis. Spector, T.D., Roman, E., Silman, A.J. Arthritis Rheum. (1990) [Pubmed]
  25. Identification of 12 novel mutations and two new polymorphisms in the arylsulfatase A gene: haplotype and genotype-phenotype correlation studies in Spanish metachromatic leukodystrophy patients. Gort, L., Coll, M.J., Chabás, A. Hum. Mutat. (1999) [Pubmed]
  26. Increased adipose-tissue lipoprotein-lipase activity in moderately obese men after weight reduction. Schwartz, R.S., Brunzell, J.D. Lancet (1978) [Pubmed]
  27. Two-color immunofluorescence and flow cytometry analysis of lymphocytes in long-term renal allotransplant recipients: identification of a major Leu-7+/Leu-3+ subpopulation. Legendre, C.M., Guttmann, R.D., Hou, S.K., Jean, R. J. Immunol. (1985) [Pubmed]
  28. Dietary fruit and vegetables protect against somatic mutation in vivo, but low or high intake of carotenoids does not. Nyberg, F., Hou, S.M., Pershagen, G., Lambert, B. Carcinogenesis (2003) [Pubmed]
  29. Fatty acid oxidation in peripheral blood cells: characterization and use for the diagnosis of defects of fatty acid oxidation. Schaefer, J., Pourfarzam, M., Bartlett, K., Jackson, S., Turnbull, D.M. Pediatr. Res. (1995) [Pubmed]
  30. A study of histocompatibility antigens in patients with motor neuron disease in the northern region of England. Woo, E., Nightingale, S., Dick, D.J., Walls, T.J., French, J.M., Bates, D. J. Neurol. Neurosurg. Psychiatr. (1986) [Pubmed]
  31. In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. Petersen, C.I., McFarland, T.R., Stepanovic, S.Z., Yang, P., Reiner, D.J., Hayashi, K., George, A.L., Roden, D.M., Thomas, J.H., Balser, J.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  32. Heparin-induced thrombocytopenia: confirmation of diagnosis with in vitro methods. Fratantoni, J.C., Pollet, R., Gralnick, H.R. Blood (1975) [Pubmed]
  33. Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer. Flasshove, M., Banerjee, D., Mineishi, S., Li, M.X., Bertino, J.R., Moore, M.A. Blood (1995) [Pubmed]
  34. Lack of late toxicity in patients treated with cisplatin-containing combination chemotherapy for metastatic testicular cancer. Boyer, M., Raghavan, D., Harris, P.J., Lietch, J., Bleasel, A., Walsh, J.C., Anderson, S., Tsang, C.S. J. Clin. Oncol. (1990) [Pubmed]
  35. Monoaminergic and cholinergic synaptic markers in the nucleus basalis of Meynert (nbM): normal age-related changes and the effect of heart disease and Alzheimer's disease. Sparks, D.L., Hunsaker, J.C., Slevin, J.T., DeKosky, S.T., Kryscio, R.J., Markesbery, W.R. Ann. Neurol. (1992) [Pubmed]
  36. A novel allelic variant of serum amyloid A, SAA1 gamma: genomic evidence, evolution, frequency, and implication as a risk factor for reactive systemic AA-amyloidosis. Baba, S., Masago, S.A., Takahashi, T., Kasama, T., Sugimura, H., Tsugane, S., Tsutsui, Y., Shirasawa, H. Hum. Mol. Genet. (1995) [Pubmed]
  37. EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer. Jagmohan-Changur, S., Poikonen, T., Vilkki, S., Launonen, V., Wikman, F., Orntoft, T.F., Møller, P., Vasen, H., Tops, C., Kolodner, R.D., Mecklin, J.P., Järvinen, H., Bevan, S., Houlston, R.S., Aaltonen, L.A., Fodde, R., Wijnen, J., Karhu, A. Cancer Res. (2003) [Pubmed]
  38. The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype. Newton, J., Brown, M.A., Milicic, A., Ackerman, H., Darke, C., Wilson, J.N., Wordsworth, B.P., Kwiatkowski, D. Arthritis Rheum. (2003) [Pubmed]
  39. Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis. Ho, P., Bruce, I.N., Silman, A., Symmons, D., Newman, B., Young, H., Griffiths, C.E., John, S., Worthington, J., Barton, A. Arthritis Rheum. (2005) [Pubmed]
  40. Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Gaedigk, A., Bradford, L.D., Marcucci, K.A., Leeder, J.S. Clin. Pharmacol. Ther. (2002) [Pubmed]
  41. Reduction in C-reactive protein through cardiac rehabilitation and exercise training. Milani, R.V., Lavie, C.J., Mehra, M.R. J. Am. Coll. Cardiol. (2004) [Pubmed]
  42. A population-based study of the effectiveness of inferior vena cava filter use among patients with venous thromboembolism. White, R.H., Zhou, H., Kim, J., Romano, P.S. Arch. Intern. Med. (2000) [Pubmed]
  43. Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. Takimoto, C.H., Lu, Z.H., Zhang, R., Liang, M.D., Larson, L.V., Cantilena, L.R., Grem, J.L., Allegra, C.J., Diasio, R.B., Chu, E. Clin. Cancer Res. (1996) [Pubmed]
  44. Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls. Zheng, Y.L., Loffredo, C.A., Yu, Z., Jones, R.T., Krasna, M.J., Alberg, A.J., Yung, R., Perlmutter, D., Enewold, L., Harris, C.C., Shields, P.G. Carcinogenesis (2003) [Pubmed]
  45. Kallikrein excretion in renal transplant recipients and in uninephrectomized donors. Spragg, J., Denney, D.L., Tilney, N.L., Austen, K.F. Kidney Int. (1985) [Pubmed]
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