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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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ATP1B1  -  ATPase, Na+/K+ transporting, beta 1...

Homo sapiens

Synonyms: ATP1B, Sodium/potassium-dependent ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit beta-1
 
 
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High impact information on ATP1B1

  • Our genomewide linkage and candidate-gene-based association studies demonstrate that a replicated linkage peak for BP regulation on human chromosome 1q, homologous to mouse and rat quantitative trait loci for BP, contains at least three genes associated with BP levels in multiple samples: ATP1B1, RGS5, and SELE [1].
  • The second class, designated ATP1B, includes 15 overlapping genomic clones and represents a functional gene for the human Na,K-ATPase beta subunit [2].
  • Two of the 12 GC boxes (GGCGGG and CCCGCC) located in the 5' region of ATP1B are located between this CAAT box and the proximal clusters of transcription initiation sites [2].

References

  1. Multiple genes for essential-hypertension susceptibility on chromosome 1q. Chang, Y.P., Liu, X., Kim, J.D., Ikeda, M.A., Layton, M.R., Weder, A.B., Cooper, R.S., Kardia, S.L., Rao, D.C., Hunt, S.C., Luke, A., Boerwinkle, E., Chakravarti, A. Am. J. Hum. Genet. (2007) [Pubmed]
  2. Characterization of two genes for the human Na,K-ATPase beta subunit. Lane, L.K., Shull, M.M., Whitmer, K.R., Lingrel, J.B. Genomics (1989) [Pubmed]
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