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Gene Review

SELE  -  selectin E

Homo sapiens

Synonyms: CD62 antigen-like family member E, CD62E, E-selectin, ELAM, ELAM-1, ...
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Disease relevance of SELE


Psychiatry related information on SELE


High impact information on SELE


Chemical compound and disease context of SELE


Biological context of SELE

  • Our results suggest an age-specific effect of the SELE L/F554 polymorphism on blood pressure levels [14].
  • Measurements of blood pressure 11 years before (t(-11)) and at the time of recruitment (t(0)), and all other measurements necessary for the analysis (body mass index, lipids, SELE genotypes) were available [14].
  • The location of SELE on chicken Chr 8 was independently established by linkage analysis of COM0185, an (AT)16 microsatellite locus identified in a BAC clone that contained SELE [15].
  • The association between the IL-1 system and atherosclerosis is complex and may vary as a result of a number of factors, such as stage of disease, clinical phenotype, and possibly population characteristics.The E-selectin gene (SELE) Arg128, 98T, and Phe554 alleles may increase the risk of atherosclerosis, but not necessarily the risk of MI [16].
  • Methods: Primary cultures of HVEC were examined for expression of the adhesion molecules ICAM1, VCAM1 and E-selectin (SELE) after non viral siRNA transfection [17].

Anatomical context of SELE

  • Three differentially expressed selectin genes (SELE, SELP, and SELL), important in the initial stages of leukocyte extravasation, have been reported in mammals [15].
  • Expression of ELAM-1 transcripts in cultured human endothelial cells is induced by cytokines, reaching a maximum at 2 to 4 hours and decaying by 24 hours; cell surface expression of ELAM-1 protein parallels that of the mRNA [18].
  • A full-length complementary DNA (cDNA) for ELAM-1 has now been isolated by transient expression in COS cells [18].
  • In contrast the activation-independent adhesion of CD4+ T cell to ELAM-1 molecules does not lead to T cell stimulation as measured by proliferation, IL-2R alpha expression, or cytokine release [19].
  • These data document distinct roles for ICAM-1, ELAM-1, and VCAM-1 during basophil, eosinophil, and neutrophil adhesion in vitro, and suggest a novel mechanism for the recruitment of eosinophils and basophils to sites of inflammation in vivo [20].

Associations of SELE with chemical compounds


Physical interactions of SELE


Regulatory relationships of SELE


Other interactions of SELE


Analytical, diagnostic and therapeutic context of SELE


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  2. Granule membrane protein 140 (GMP140) binds to carcinomas and carcinoma-derived cell lines. Aruffo, A., Dietsch, M.T., Wan, H., Hellström, K.E., Hellström, I. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Cytokine production (IL-1 alpha, IL-1 beta, and TNF alpha) and endothelial cell activation (ELAM-1 and HLA-DR) in reactive lymphadenitis, Hodgkin's disease, and in non-Hodgkin's lymphomas. An immunocytochemical study. Ruco, L.P., Pomponi, D., Pigott, R., Stoppacciaro, A., Monardo, F., Uccini, S., Boraschi, D., Tagliabue, A., Santoni, A., Dejana, E. Am. J. Pathol. (1990) [Pubmed]
  4. Identical expression of ELAM-1, VCAM-1, and ICAM-1 in sarcoidosis and usual interstitial pneumonitis. van Dinther-Janssen, A.C., van Maarsseveen, T.C., Eckert, H., Newman, W., Meijer, C.J. J. Pathol. (1993) [Pubmed]
  5. Serum levels of soluble intercellular adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1 in Alzheimer's disease. Rentzos, M., Michalopoulou, M., Nikolaou, C., Cambouri, C., Rombos, A., Dimitrakopoulos, A., Kapaki, E., Vassilopoulos, D. Journal of geriatric psychiatry and neurology. (2004) [Pubmed]
  6. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Picker, L.J., Warnock, R.A., Burns, A.R., Doerschuk, C.M., Berg, E.L., Butcher, E.C. Cell (1991) [Pubmed]
  7. ELFT: a gene that directs the expression of an ELAM-1 ligand. Goelz, S.E., Hession, C., Goff, D., Griffiths, B., Tizard, R., Newman, B., Chi-Rosso, G., Lobb, R. Cell (1990) [Pubmed]
  8. ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Lowe, J.B., Stoolman, L.M., Nair, R.P., Larsen, R.D., Berhend, T.L., Marks, R.M. Cell (1990) [Pubmed]
  9. PMN adhesion and extravasation as a paradigm for tumor cell dissemination. Smith, C.W., Anderson, D.C. Cancer Metastasis Rev. (1991) [Pubmed]
  10. ELAM selectin expression in breast carcinomas detected by automated and quantitative immunohistochemical assays. Charpin, C., Bergeret, D., Garcia, S., Andrac, L., Martini, F., Horschowski, N., Choux, R., Lavaut, M.N. Int. J. Oncol. (1998) [Pubmed]
  11. High-level endothelial E-selectin (CD62E) cell adhesion molecule expression by a lipopolysaccharide-deficient strain of Neisseria meningitidis despite poor activation of NF-kappaB transcription factor. Dixon, G.L., Heyderman, R.S., van der Ley, P., Klein, N.J. Clin. Exp. Immunol. (2004) [Pubmed]
  12. Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment. Caproni, M., Volpi, W., Giomi, B., Torchia, D., Del Bianco, E., Fabbri, P. Br. J. Dermatol. (2006) [Pubmed]
  13. Monitoring of disease activity by measurement of inflammatory markers in atopic dermatitis in childhood. Halmerbauer, G., Frischer, T., Koller, D.Y. Allergy (1997) [Pubmed]
  14. Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort. Sass, C., Pallaud, C., Zannad, F., Visvikis, S. Hum. Genet. (2000) [Pubmed]
  15. The genes encoding E-selectin (SELE) and lymphotactin (SCYC1) lie on separate chicken chromosomes although they are closely linked in human and mouse. Morroll, S., Goodchild, M., Salmon, N., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Bumstead, N., Boyd, Y. Immunogenetics (2001) [Pubmed]
  16. Genetic polymorphisms in cytokine and adhesion molecule genes in coronary artery disease. Auer, J., Weber, T., Berent, R., Lassnig, E., Lamm, G., Eber, B. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. (2003) [Pubmed]
  17. Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection. Walker, T., Wendel, H.P., Tetzloff, L., Raabe, C., Heidenreich, O., Simon, P., Scheule, A.M., Ziemer, G. J. Cell. Mol. Med. (2007) [Pubmed]
  18. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Bevilacqua, M.P., Stengelin, S., Gimbrone, M.A., Seed, B. Science (1989) [Pubmed]
  19. Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1. van Seventer, G.A., Newman, W., Shimizu, Y., Nutman, T.B., Tanaka, Y., Horgan, K.J., Gopal, T.V., Ennis, E., O'Sullivan, D., Grey, H. J. Exp. Med. (1991) [Pubmed]
  20. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. Bochner, B.S., Luscinskas, F.W., Gimbrone, M.A., Newman, W., Sterbinsky, S.A., Derse-Anthony, C.P., Klunk, D., Schleimer, R.P. J. Exp. Med. (1991) [Pubmed]
  21. Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Montgomery, K.F., Osborn, L., Hession, C., Tizard, R., Goff, D., Vassallo, C., Tarr, P.I., Bomsztyk, K., Lobb, R., Harlan, J.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  22. Labile proteins play a dual role in the control of endothelial leukocyte adhesion molecule-1 (ELAM-1) gene regulation. Ghersa, P., Hooft van Huijsduijnen, R., Whelan, J., DeLamarter, J.F. J. Biol. Chem. (1992) [Pubmed]
  23. Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. Luscinskas, F.W., Brock, A.F., Arnaout, M.A., Gimbrone, M.A. J. Immunol. (1989) [Pubmed]
  24. Activation-independent binding of human memory T cells to adhesion molecule ELAM-1. Shimizu, Y., Shaw, S., Graber, N., Gopal, T.V., Horgan, K.J., Van Seventer, G.A., Newman, W. Nature (1991) [Pubmed]
  25. Tumor necrosis factor and interferon-gamma induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of Papio anubis. Munro, J.M., Pober, J.S., Cotran, R.S. Am. J. Pathol. (1989) [Pubmed]
  26. Modulation of adhesion molecule expression on endothelial cells by verapamil and other Ca++ channel blockers. Hailer, N.P., Blaheta, R.A., Harder, S., Scholz, M., Encke, A., Markus, B.H. Immunobiology (1994) [Pubmed]
  27. Expression of adhesion molecules and monocyte chemoattractant protein -1 (MCP-1) in the spinal cord lesions in HTLV-I-associated myelopathy. Umehara, F., Izumo, S., Takeya, M., Takahashi, K., Sato, E., Osame, M. Acta Neuropathol. (1996) [Pubmed]
  28. Localization of IL-1 beta mRNA and cell adhesion molecules in the maxillary sinus mucosa of patients with chronic sinusitis. Tokushige, E., Itoh, K., Ushikai, M., Katahira, S., Fukuda, K. Laryngoscope (1994) [Pubmed]
  29. Activated eosinophils upregulate the metastasis suppressor molecule E-cadherin on prostate tumor cells. Furbert-Harris, P.M., Parish-Gause, D., Hunter, K.A., Vaughn, T.R., Howland, C., Okomo-Awich, J., Forrest, K., Laniyan, I., Abdelnaby, A., Oredipe, O.A. Cell. Mol. Biol. (Noisy-le-grand) (2003) [Pubmed]
  30. Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1. Weller, P.F., Rand, T.H., Goelz, S.E., Chi-Rosso, G., Lobb, R.R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  31. Modulation of human endothelial cell activation by antiproliferative cytokines: exploration of arachidonic acid and intracellular cytokine pathways as possible mechanisms of action. Delomenie, C., Wautier-Pepin, M.P., Chappey, O., Wautier, J.L. Exp. Cell Res. (1993) [Pubmed]
  32. Expression of intercellular adhesion molecule 1 (ICAM-1) on human articular cartilage chondrocytes. Davies, M.E., Dingle, J.T., Pigott, R., Power, C., Sharma, H. Connect. Tissue Res. (1991) [Pubmed]
  33. Influence of angiotensin-converting enzyme inhibitor enalaprilat on endothelial-derived substances in the critically ill. Boldt, J., Papsdorf, M., Kumle, B., Piper, S., Hempelmann, G. Crit. Care Med. (1998) [Pubmed]
  34. Murine endothelial leukocyte-adhesion molecule 1 is a close structural and functional homologue of the human protein. Becker-André, M., Hooft van Huijsduijnen, R., Losberger, C., Whelan, J., Delamarter, J.F. Eur. J. Biochem. (1992) [Pubmed]
  35. Endothelial cell response to hypoxia-reoxygenation is mediated by IL-1. Clark, E.T., Desai, T.R., Hynes, K.L., Gewertz, B.L. J. Surg. Res. (1995) [Pubmed]
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