Disease relevance of l(2)gd1

• Recessive lethal mutations of the lethal(2)giant discs (l(2)gd ) and lethal(2)fat (l(2)ft ) loci of Drosophila melanogaster cause imaginal disc hyperplasia during a prolonged larval stage [1].

Biological context of l(2)gd1

• Lethal giant discs, a novel C2-domain protein, restricts Notch activation during endocytosis. [2]
• The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking. [3]
• The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila. [4]
• The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development [5].
• Duplication of l(2)gd imaginal discs in Drosophila is mediated by ectopic expression of wg and dpp. [6]

References