Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

wek - weckle

Drosophila melanogaster

Synonyms: BG:DS09217.5, CG4148, Dmel\CG4148, Zinc finger protein weckle, l(2)35Ea, ...

Chen, L.Y. et al.

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Disease relevance of wek

Remarkably, unlike the DmMyD88/tube/pelle/cactus gene cassette of the Toll pathway, wek plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi [1].

High impact information on wek

Unexpectedly, wek is dispensable for innate immune response, thus revealing differences in the Toll-mediated activation of Dorsal in the embryo and Dif in the fat body of adult flies [1].
Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo [1].

References

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Chen, L.Y., Wang, J.C., Hyvert, Y., Lin, H.P., Perrimon, N., Imler, J.L., Hsu, J.C. Curr. Biol. (2006) [Pubmed]

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