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Gene Review:

Cd8ts1 - CD8 T cell subset 1

Mus musculus

Torres-Nagel, N. et al., Podlech, J. et al., Telford, W.G. et al., Pohl, J. et al.

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High impact information on Cd8ts1

TCRAV segments contribute significantly to MHC restriction as illustrated by their general preference for either the CD4 or CD8 T cell subset and additional, MHC allele-specific overselection during T cell differentiation [1].
This "agonist withdrawal" cell death occurred largely within the CD8 T cell subset, with CD4 cells showing lower levels of apoptosis [2].
Transcription of retinoic acid receptor genes in transgenic mice increases CD8 T-cell subset [3].

Anatomical context of Cd8ts1

Specifically, in a state of long-term in vivo depletion of the CD8 T-cell subset, CD4 T cells were educed to become deputy effectors controlling CMV by a mechanism involving antiviral cytokines [4].

References

Genetic control of peripheral TCRAV usage by representation in the preselection repertoire and MHC allele-specific overselection. Torres-Nagel, N., Mehling, B., LeRolle, A.F., Joly, E., Hünig, T. Int. Immunol. (2001) [Pubmed]
CD30-regulated apoptosis in murine CD8 T cells after cessation of TCR signals. Telford, W.G., Nam, S.Y., Podack, E.R., Miller, R.A. Cell. Immunol. (1997) [Pubmed]
Transcription of retinoic acid receptor genes in transgenic mice increases CD8 T-cell subset. Pohl, J., LaFace, D., Sands, J.F. Mol. Biol. Rep. (1993) [Pubmed]
Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation. Podlech, J., Holtappels, R., Wirtz, N., Steffens, H.P., Reddehase, M.J. J. Gen. Virol. (1998) [Pubmed]

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