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Gene Review

NVL  -  nuclear VCP-like

Homo sapiens

Synonyms: NVLp, Nuclear VCP-like protein, Nuclear valosin-containing protein-like
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Disease relevance of NVL

  • Whereas greater than 90% of poliovirus types 2 and 3 were found to be VL in the KSN test, 40% of type 1 isolates were classified as NVL . The latter were detected not only in the epidemics of 1962 and 1978-1979 caused by type 1 poliovirus but also were present in endemic form in the late 1960s and 1970s in various provinces [1].

High impact information on NVL

  • We have modulated the cellular levels of these two reactive oxygen species in order to compare their involvement in the induction of the human heme oxygenase (HO) gene by broad spectrum UVA/near-visible light (UVA/NVL) [2].
  • Patients with tumor extending to or through the prostatic capsule, extending to or near the surgical margins, involving the seminal vesicles, or having NVL invasion all may benefit from adjuvant irradiation in the immediate perioperative period [3].


  1. Genetic characterization of poliovirus isolates in Canada, 1962-1981. Furesz, J., Armstrong, R.E., Contreras, G., Wachmann, B. Rev. Infect. Dis. (1984) [Pubmed]
  2. Singlet oxygen: a primary effector in the ultraviolet A/near-visible light induction of the human heme oxygenase gene. Basu-Modak, S., Tyrrell, R.M. Cancer Res. (1993) [Pubmed]
  3. The role of adjuvant irradiation following primary prostatectomy, based on histopathologic extent of tumor. Shevlin, B.E., Mittal, B.B., Brand, W.N., Shetty, R.M. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
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