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MeSH Review

Seminal Vesicles

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Disease relevance of Seminal Vesicles


Psychiatry related information on Seminal Vesicles

  • We measured the following: weight at birth and over a 5-mo period; sexual behavior of adult males; curiosity; basal physical activity; morphometric measures; organ weights (absolute and relative) including brain, testicles and seminal vesicles in males 5 mo of age; and the O2 uptake of some brain and glandular structures in males at 5 mo of age [6].
  • Androgenic status and libido as assessed by seminal fructose, seminal vesicle weight, seminal fructose and reaction time were not affected by the disease [7].

High impact information on Seminal Vesicles


Chemical compound and disease context of Seminal Vesicles


Biological context of Seminal Vesicles


Anatomical context of Seminal Vesicles


Associations of Seminal Vesicles with chemical compounds

  • Animals fed a diet with ethanol accounting for 36% of total calories develop significant testicular, prostatic, and seminal vesicle atrophy (P less than 0.01) and greatly reduced plasma testosterone levels (P less than 0.01) [27].
  • Ventral prostate and seminal vesicle weights were less in cimetidine-treated castrate adult male rats androgenized with testosterone-filled subcutaneous silastic capsules than in vehicle-injected controls [28].
  • Rat seminal vesicles serve as a model system for studying androgen action [29].
  • Staining of the cells with a peroxidase-conjugated antibody and analysis of the proteins produced in the presence of labelled methionine, showed that one of the major rat seminal vesicle secretory proteins, namely RSV-IV, was also produced [30].
  • Docosahexaenoic acid (DCHA), a major polyunsaturated acid component of fish lipid, is not a substrate for prostaglandin synthetase from ram seminal vesicles but is a strong competitive inhibitor (Ki, 0.36 microM) of the conversion by this enzyme of arachidonate (Km, 5.9 microM) to prostaglandins [31].

Gene context of Seminal Vesicles


Analytical, diagnostic and therapeutic context of Seminal Vesicles

  • Therefore, the optimal candidate for local-only salvage therapy is a man whose pretreatment PSA velocity was 2 ng/mL/year or less, interval to PSA failure exceeds 3 years, and post-treatment PSA doubling time is at least 12 months, and who did not have biopsy or prostatectomy Gleason score of 8 to 10 or seminal vesicle or lymph node involvement [37].
  • Multivariate analysis, which was limited to 70 patients receiving radiation without androgen deprivation therapy, showed that negative/close margins (P =.03), absence of extracapsular extension (P <.01), and presence of seminal vesicle invasion (P <.01) were independent predictors of PSA relapse after radiotherapy [38].
  • Antiangiogenic treatment with linomide as chemoprevention for prostate, seminal vesicle, and breast carcinogenesis in rodents [39].
  • Significant variables in the multivariable model included PSA (P = .002), primary (P < .0001) and secondary Gleason grade (P = .0006), extracapsular extension (P < .0001), positive surgical margins (P = .028), seminal vesicle invasion (P < .0001), lymph node involvement (P = .030), treatment year (P = .008), and adjuvant radiotherapy (P = .046) [40].
  • The size of androgen receptors from rat ventral and dorsal prostate, dorsal prostate (Dunning) tumor, testis, epididymis, and seminal vesicle was determined using Sephadex G-200 chromatogrpahy and sucrose gradient centrifugation [41].


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  17. Acetylation of prostaglandin synthase by aspirin. Roth, G.J., Stanford, N., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
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  23. CFTR gene mutations in men with bilateral ejaculatory-duct obstruction and anomalies of the seminal vesicles. Meschede, D., Dworniczak, B., Behre, H.M., Kliesch, S., Claustres, M., Nieschlag, E., Horst, J. Am. J. Hum. Genet. (1997) [Pubmed]
  24. Identification and characterization of a vasopressin isoreceptor in porcine seminal vesicles. Maggi, M., Kassis, S., Malozowski, S., Guardabasso, V., Rodbard, D. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  25. Phosphocreatine, an intracellular high-energy compound, is found in the extracellular fluid of the seminal vesicles in mice and rats. Lee, H.J., Fillers, W.S., Iyengar, M.R. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
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  32. Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. Bylund, J., Hidestrand, M., Ingelman-Sundberg, M., Oliw, E.H. J. Biol. Chem. (2000) [Pubmed]
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  38. Predictors of biochemical outcome with salvage conformal radiotherapy after radical prostatectomy for prostate cancer. Katz, M.S., Zelefsky, M.J., Venkatraman, E.S., Fuks, Z., Hummer, A., Leibel, S.A. J. Clin. Oncol. (2003) [Pubmed]
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