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Gene Review:

OFC2 - orofacial cleft 2

Homo sapiens

Pezzetti, F. et al., Carinci, F. et al.

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High impact information on OFC2

Taken together these results indicate a role for the TGFA, or for another gene physically close to it, and suggest an interaction between two different genes, OFC1 and OFC2, mapped in 6p23 and 2p13, respectively, in the development of the cleft [1].
A locus in 2p13-p14 (OFC2), in addition to that mapped in 6p23, is involved in nonsyndromic familial orofacial cleft malformation [1].
Genetic heterogeneity has been observed in CL+/-P, which involves different chromosome regions, mainly 6p23 (OFC1), 2q13 (OFC2), and 19q13.2 (OFC3), as well as other loci, such as 4q25-4q31.3 and 17q21 [2].

References

A locus in 2p13-p14 (OFC2), in addition to that mapped in 6p23, is involved in nonsyndromic familial orofacial cleft malformation. Pezzetti, F., Scapoli, L., Martinelli, M., Carinci, F., Bodo, M., Carinci, P., Tognon, M. Genomics (1998) [Pubmed]
Genetics of nonsyndromic cleft lip and palate: a review of international studies and data regarding the Italian population. Carinci, F., Pezzetti, F., Scapoli, L., Martinelli, M., Carinci, P., Tognon, M. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (2000) [Pubmed]

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