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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DEF6  -  differentially expressed in FDCP 6 homolog...

Homo sapiens

Synonyms: DEF-6, Differentially expressed in FDCP 6 homolog, IBP, IRF4-binding protein, SLAT, ...
 
 
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High impact information on DEF6

  • Finally, we succeeded in creating mutants of DEF6 with point mutations in the amino-terminal portion, which abrogate the binding to activated Rac1 [1].
  • This effect of DEF6 on cellular morphology was shown to be independent of its guanine nucleotide exchange activity [1].
  • DEF6, a pleckstrin homology domain-containing protein, has been reported to regulate Rho-family GTPases as a guanine nucleotide exchange factor [1].
  • The ability of DEF6 to both stimulate actin polymerization and bind to filamentous actin suggests a role for DEF6 in regulating cell shape, polarity, and movement [2].

References

  1. Cooperation of DEF6 with activated Rac in regulating cell morphology. Oka, T., Ihara, S., Fukui, Y. J. Biol. Chem. (2007) [Pubmed]
  2. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. Mavrakis, K.J., McKinlay, K.J., Jones, P., Sablitzky, F. Exp. Cell Res. (2004) [Pubmed]
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