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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Shape

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Disease relevance of Cell Shape


Psychiatry related information on Cell Shape

  • These phenotypes are accompanied by an arrest of the cell shape changes normally occurring in lateral epidermis and in epithelial midgut cells. l(2)gl activity is also necessary for larval fife and the critical period falls within the third instar larval stage [6].

High impact information on Cell Shape

  • Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation [7].
  • Loss of Mig-2 or migfilin impairs cell shape modulation [7].
  • In the absence of proteolysis, tumor cells embedded in physiologically relevant ECM matrices are trapped in a compact, spherical configuration and unable to undergo changes in cell shape or cytoskeletal reorganization required for 3D growth [8].
  • Rather than integrating proliferative signals, Shp2 probably exerts its effects on limb development by influencing cell shape, movement or adhesion [9].
  • These findings suggest that dynamic changes in actin filaments alter cell shape to control the movement of signals that coordinate a wave of differentiation [10].

Chemical compound and disease context of Cell Shape


Biological context of Cell Shape


Anatomical context of Cell Shape


Associations of Cell Shape with chemical compounds

  • Mutations in Drosophila scribble (scrib), which encodes a multi-PDZ (PSD-95, Discs-large and ZO-1) and leucine-rich-repeat protein, cause aberrant cell shapes and loss of the monolayer organization of embryonic epithelia [26].
  • Cell shape was found to govern whether individual cells grow or die, regardless of the type of matrix protein or antibody to integrin used to mediate adhesion [27].
  • These patterns were correlated with those of cell shape change that propagate through the monolayers: cells in regions of high concentrations of cyclic AMP were elongated (presumably moving up a cyclic AMP gradient), whereas those in regions of low cyclic AMP concentrations were randomly directed [28].
  • Normalization of the C/P of spur serum by added phospholipid prevented the increase in membrane cholesterol and surface area and the transformation of cell shape [29].
  • As assessed by cell shape change, preincubation with 10(-5) M ouabain for 60 min also enhanced the sustained cellular contractile effect of a submaximal (10(-8) M AVP, 21.5% vs. 30.5%, P less than 0.01) but not maximal dose of 10(-6) M AVP [30].

Gene context of Cell Shape

  • When activated by specific stresses that alter cell shape and the cytoskeleton, MEKK1 signals to protect cells from apoptosis [31].
  • Characterization of a loss-of-function mutant of Drosophila Pkn revealed that this kinase is required specifically for the epidermal cell shape changes during the morphogenetic process of dorsal closure of the developing embryo [32].
  • These observations suggest that a common cdc42-based mechanism may govern polarized cell shape changes in a wide variety of cell types [33].
  • Occupation of uPAR elicited a time-dependent increase in the phosphorylation intensity of CK8, a cell shape change and a redistribution of the cytokeratin filaments [34].
  • Embryos completely lacking both maternal and zygotic Abl die with defects in several morphogenetic processes requiring cell shape changes and cell migration [35].

Analytical, diagnostic and therapeutic context of Cell Shape


  1. Correlation of frequency of induced mutation and metastatic potential in tumor cell lines from a single mouse mammary tumor. Yamashina, K., Heppner, G.H. Cancer Res. (1985) [Pubmed]
  2. Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells. Chintala, S.K., Sawaya, R., Aggarwal, B.B., Majumder, S., Giri, D.K., Kyritsis, A.P., Gokaslan, Z.L., Rao, J.S. J. Biol. Chem. (1998) [Pubmed]
  3. ppGpp concentration, growth without PBP2 activity, and growth-rate control in Escherichia coli. Joseleau-Petit, D., Thévenet, D., D'Ari, R. Mol. Microbiol. (1994) [Pubmed]
  4. Control of cell shape and elongation by the rodA gene in Bacillus subtilis. Henriques, A.O., Glaser, P., Piggot, P.J., Moran, C.P. Mol. Microbiol. (1998) [Pubmed]
  5. Dependence of proliferation of Bacteroides forsythus on exogenous N-acetylmuramic acid. Wyss, C. Infect. Immun. (1989) [Pubmed]
  6. The tumor suppressor gene, lethal(2)giant larvae (1(2)g1), is required for cell shape change of epithelial cells during Drosophila development. Manfruelli, P., Arquier, N., Hanratty, W.P., Sémériva, M. Development (1996) [Pubmed]
  7. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Tu, Y., Wu, S., Shi, X., Chen, K., Wu, C. Cell (2003) [Pubmed]
  8. Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Hotary, K.B., Allen, E.D., Brooks, P.C., Datta, N.S., Long, M.W., Weiss, S.J. Cell (2003) [Pubmed]
  9. The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. Saxton, T.M., Ciruna, B.G., Holmyard, D., Kulkarni, S., Harpal, K., Rossant, J., Pawson, T. Nat. Genet. (2000) [Pubmed]
  10. act up controls actin polymerization to alter cell shape and restrict Hedgehog signaling in the Drosophila eye disc. Benlali, A., Draskovic, I., Hazelett, D.J., Treisman, J.E. Cell (2000) [Pubmed]
  11. A 60-kilodalton immunodominant glycoprotein is essential for cell wall integrity and the maintenance of cell shape in Streptococcus mutans. Chia, J.S., Chang, L.Y., Shun, C.T., Chang, Y.Y., Tsay, Y.G., Chen, J.Y. Infect. Immun. (2001) [Pubmed]
  12. Multiple neurite formation in neuroblastoma cell lines by griseolic acid, a potent inhibitor of cyclic nucleotide phosphodiesterases. Mitsui, K., Tsuji, S., Yamazaki, M., Nagai, Y. J. Neurochem. (1991) [Pubmed]
  13. Effect of thymine concentration on cell shape in Thy- Escherichia coli B/r. Meacock, P.A., Pritchard, R.H., Roberts, E.M. J. Bacteriol. (1978) [Pubmed]
  14. Detergent-resistant variants of Bacillus subtilis with reduced cell diameter. Tilby, M.J. J. Bacteriol. (1978) [Pubmed]
  15. Dissociation of tubular cell detachment and tubular cell death in clinical and experimental "acute tubular necrosis". Racusen, L.C., Fivush, B.A., Li, Y.L., Slatnik, I., Solez, K. Lab. Invest. (1991) [Pubmed]
  16. A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila. Grosshans, J., Wieschaus, E. Cell (2000) [Pubmed]
  17. Role of band 3 in homeostasis and cell shape. Jay, D.G. Cell (1996) [Pubmed]
  18. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Hart, M.J., Eva, A., Evans, T., Aaronson, S.A., Cerione, R.A. Nature (1991) [Pubmed]
  19. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Kheradmand, F., Werner, E., Tremble, P., Symons, M., Werb, Z. Science (1998) [Pubmed]
  20. Tyrosine phosphorylation of actin in Dictyostelium associated with cell-shape changes. Howard, P.K., Sefton, B.M., Firtel, R.A. Science (1993) [Pubmed]
  21. Ciboulot regulates actin assembly during Drosophila brain metamorphosis. Boquet, I., Boujemaa, R., Carlier, M.F., Préat, T. Cell (2000) [Pubmed]
  22. Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. Fong, A.M., Robinson, L.A., Steeber, D.A., Tedder, T.F., Yoshie, O., Imai, T., Patel, D.D. J. Exp. Med. (1998) [Pubmed]
  23. Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes. Kuroda, T.S., Fukuda, M. Nat. Cell Biol. (2004) [Pubmed]
  24. Immunological characterization of a major transformation-sensitive fibroblast cell surface glycoprotein. Localization, redistribution, and role in cell shape. Yamada, K.M. J. Cell Biol. (1978) [Pubmed]
  25. Glucocorticoid hormone modulation of both cell surface and cytoskeleton related to growth control of rat glioma cells. Armelin, M.C., Armelin, H.A. J. Cell Biol. (1983) [Pubmed]
  26. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Bilder, D., Perrimon, N. Nature (2000) [Pubmed]
  27. Geometric control of cell life and death. Chen, C.S., Mrksich, M., Huang, S., Whitesides, G.M., Ingber, D.E. Science (1997) [Pubmed]
  28. Adenosine 3',5'-monophosphate waves in Dictyostelium discoideum: a demonstration by isotope dilution--fluorography. Tomchik, K.J., Devreotes, P.N. Science (1981) [Pubmed]
  29. Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect. Cooper, R.A., Arner, E.C., Wiley, J.S., Shattil, S.J. J. Clin. Invest. (1975) [Pubmed]
  30. Effect of inhibition of Na+/K(+)-adenosine triphosphatase on vascular action of vasopressin. Okada, K., Caramelo, C., Tsai, P., Schrier, R.W. J. Clin. Invest. (1990) [Pubmed]
  31. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Yujiri, T., Sather, S., Fanger, G.R., Johnson, G.L. Science (1998) [Pubmed]
  32. The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Lu, Y., Settleman, J. Genes Dev. (1999) [Pubmed]
  33. CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. Eaton, S., Auvinen, P., Luo, L., Jan, Y.N., Simons, K. J. Cell Biol. (1995) [Pubmed]
  34. Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells. Busso, N., Masur, S.K., Lazega, D., Waxman, S., Ossowski, L. J. Cell Biol. (1994) [Pubmed]
  35. Abelson kinase regulates epithelial morphogenesis in Drosophila. Grevengoed, E.E., Loureiro, J.J., Jesse, T.L., Peifer, M. J. Cell Biol. (2001) [Pubmed]
  36. Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. Kiehart, D.P., Galbraith, C.G., Edwards, K.A., Rickoll, W.L., Montague, R.A. J. Cell Biol. (2000) [Pubmed]
  37. Shape-dependent regulation of proliferation in normal and malignant human cells and its alteration by interferon. Kulesh, D.A., Greene, J.J. Cancer Res. (1986) [Pubmed]
  38. Hyperactivation of the folded gastrulation pathway induces specific cell shape changes. Morize, P., Christiansen, A.E., Costa, M., Parks, S., Wieschaus, E. Development (1998) [Pubmed]
  39. Three intracellular signals for cytotoxic T lymphocyte-mediated killing. Independent roles for protein kinase C, Ca2+ influx, and Ca2+ release from internal stores. Haverstick, D.M., Engelhard, V.H., Gray, L.S. J. Immunol. (1991) [Pubmed]
  40. Requirements for alpha(5)beta(1) integrin-mediated retraction of fibronectin-fibrin matrices. Corbett, S.A., Schwarzbauer, J.E. J. Biol. Chem. (1999) [Pubmed]
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