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Gene Review

SPOCK3  -  sparc/osteonectin, cwcv and kazal-like...

Homo sapiens

Synonyms: HSAJ1454, SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3, TES-3, TICN3, Testican-3, ...
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Disease relevance of SPOCK3

  • Expression of N-Tes and testican 3 was detected in normal brain but down-regulated in glioma tissues [1].

High impact information on SPOCK3

  • Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes [1].
  • Transfection of either the N-Tes or testican 3 gene into U251 glioma cells or Madin-Darby canine kidney cells transformed by erbB2 suppressed their invasive growth in collagen gel [1].
  • N-Tes comprises a signal peptide, a unique domain, a follistatin-like domain, and a Ca(2+)-binding domain but lacks a COOH-terminal thyroglobulin domain and two putative glycosaminoglycan attachment sites of testican 3 [1].


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