Gene Review:
MMP2 - matrix metallopeptidase 2 (gelatinase A,...
Homo sapiens
Synonyms:
72 kDa gelatinase, 72 kDa type IV collagenase, CLG4, CLG4A, Gelatinase A, ...
- Cyclic AMP-regulated synthesis of the tissue inhibitors of metalloproteinases suppresses the invasive potential of the human fibrosarcoma cell line HT1080. Tanaka, K., Iwamoto, Y., Ito, Y., Ishibashi, T., Nakabeppu, Y., Sekiguchi, M., Sugioka, Y. Cancer Res. (1995)
- Torg syndrome is caused by inactivating mutations in MMP2 and is allelic to NAO and Winchester syndrome. Zankl, A., Pachman, L., Poznanski, A., Bonafé, L., Wang, F., Shusterman, Y., Fishman, D.A., Superti-Furga, A. J. Bone. Miner. Res. (2007)
- Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas. Théret, N., Musso, O., Turlin, B., Lotrian, D., Bioulac-Sage, P., Campion, J.P., Boudjéma, K., Clément, B. Hepatology (2001)
- Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. Soini, Y., Satta, J., Määttä, M., Autio-Harmainen, H. J. Pathol. (2001)
- Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. Zhou, Y., Yu, C., Miao, X., Tan, W., Liang, G., Xiong, P., Sun, T., Lin, D. Carcinogenesis (2004)
- Analysis of MT1-MMP and MMP2 expression in human gastric cancers. Mori, M., Mimori, K., Shiraishi, T., Fujie, T., Baba, K., Kusumoto, H., Haraguchi, M., Ueo, H., Akiyoshi, T. Int. J. Cancer (1997)
- Interaction between cancer cells and stromal fibroblasts is required for activation of the uPAR-uPA-MMP-2 cascade in pancreatic cancer metastasis. He, Y., Liu, X.D., Chen, Z.Y., Zhu, J., Xiong, Y., Li, K., Dong, J.H., Li, X. Clin. Cancer Res. (2007)
- Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide. Deb, S., Zhang, J.W., Gottschall, P.E. J. Neurosci. Res. (1999)
- Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells. Sakurai, D., Tsuchiya, N., Yamaguchi, A., Okaji, Y., Tsuno, N.H., Kobata, T., Takahashi, K., Tokunaga, K. J. Immunol. (2004)
- Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia. Conant, K., McArthur, J.C., Griffin, D.E., Sjulson, L., Wahl, L.M., Irani, D.N. Ann. Neurol. (1999)
- Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Burnham, E.L., Moss, M., Ritzenthaler, J.D., Roman, J. Alcohol. Clin. Exp. Res. (2007)
- Matrix metalloproteinase inhibitor RO 28-2653 decreases liver metastasis by reduction of MMP-2 and MMP-9 concentration in BOP-induced ductal pancreatic cancer in Syrian Hamsters: Inhibition of matrix metalloproteinases in pancreatic cancer. Kilian, M., Gregor, J.I., Heukamp, I., Hanel, M., Ahlgrimm, M., Schimke, I., Kristiansen, G., Ommer, A., Walz, M.K., Jacobi, C.A., Wenger, F.A. Prostaglandins Leukot. Essent. Fatty Acids (2006)
- Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Martignetti, J.A., Aqeel, A.A., Sewairi, W.A., Boumah, C.E., Kambouris, M., Mayouf, S.A., Sheth, K.V., Eid, W.A., Dowling, O., Harris, J., Glucksman, M.J., Bahabri, S., Meyer, B.F., Desnick, R.J. Nat. Genet. (2001)
- Don't mess with the matrix. Vu, T.H. Nat. Genet. (2001)
- Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Brooks, P.C., Strömblad, S., Sanders, L.C., von Schalscha, T.L., Aimes, R.T., Stetler-Stevenson, W.G., Quigley, J.P., Cheresh, D.A. Cell (1996)
- Prognostic significance of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expression in prostate cancer. Ross, J.S., Kaur, P., Sheehan, C.E., Fisher, H.A., Kaufman, R.A., Kallakury, B.V. Mod. Pathol. (2003)
- Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8. So, J., Navari, J., Wang, F.Q., Fishman, D.A. Gynecol. Oncol. (2004)
- Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. Hess, A.R., Seftor, E.A., Seftor, R.E., Hendrix, M.J. Cancer Res. (2003)
- Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. Dohadwala, M., Batra, R.K., Luo, J., Lin, Y., Krysan, K., Pold, M., Sharma, S., Dubinett, S.M. J. Biol. Chem. (2002)
- Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. Iki, K., Tsutsumi, M., Kido, A., Sakitani, H., Takahama, M., Yoshimoto, M., Motoyama, M., Tatsumi, K., Tsunoda, T., Konishi, Y. Carcinogenesis (1999)
- Platelet release of trimolecular complex components MT1-MMP/TIMP2/MMP2: involvement in MMP2 activation and platelet aggregation. Kazes, I., Elalamy, I., Sraer, J.D., Hatmi, M., Nguyen, G. Blood (2000)
- S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. Bjørnland, K., Winberg, J.O., Odegaard, O.T., Hovig, E., Loennechen, T., Aasen, A.O., Fodstad, O., Maelandsmo, G.M. Cancer Res. (1999)
- Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Galli, A., Svegliati-Baroni, G., Ceni, E., Milani, S., Ridolfi, F., Salzano, R., Tarocchi, M., Grappone, C., Pellegrini, G., Benedetti, A., Surrenti, C., Casini, A. Hepatology (2005)
- Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells. Deo, D.D., Bazan, N.G., Hunt, J.D. J. Biol. Chem. (2004)
- Down-regulation of glomerular matrix metalloproteinase-2 gene in human NIDDM. Del Prete, D., Anglani, F., Forino, M., Ceol, M., Fioretto, P., Nosadini, R., Baggio, B., Gambaro, G. Diabetologia (1997)
- MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Théret, N., Lehti, K., Musso, O., Clément, B. Hepatology (1999)
- Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control. Jimenez, R.E., Hartwig, W., Antoniu, B.A., Compton, C.C., Warshaw, A.L., Fernández-Del Castillo, C. Ann. Surg. (2000)
- Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Martin, J., Eynstone, L., Davies, M., Steadman, R. J. Am. Soc. Nephrol. (2001)
- Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. Bramhall, S.R., Neoptolemos, J.P., Stamp, G.W., Lemoine, N.R. J. Pathol. (1997)
- High glucose and homocysteine synergistically affect the metalloproteinases-tissue inhibitors of metalloproteinases pattern, but not TGFB expression, in human fibroblasts. Solini, A., Santini, E., Nannipieri, M., Ferrannini, E. Diabetologia (2006)
- Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis. Chen, H.W., Yu, S.L., Chen, J.J., Li, H.N., Lin, Y.C., Yao, P.L., Chou, H.Y., Chien, C.T., Chen, W.J., Lee, Y.T., Yang, P.C. Mol. Pharmacol. (2004)
- Focal adhesion kinase is a key mediator of human trophoblast development. MacPhee, D.J., Mostachfi, H., Han, R., Lye, S.J., Post, M., Caniggia, I. Lab. Invest. (2001)
- Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis. Hitchon, C.A., Danning, C.L., Illei, G.G., El-Gabalawy, H.S., Boumpas, D.T. J. Rheumatol. (2002)
- Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface. Itoh, Y., Ito, A., Iwata, K., Tanzawa, K., Mori, Y., Nagase, H. J. Biol. Chem. (1998)
- Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. Olson, M.W., Gervasi, D.C., Mobashery, S., Fridman, R. J. Biol. Chem. (1997)
- Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity. Bein, K., Simons, M. J. Biol. Chem. (2000)
- Matrix metalloproteinase-2 contributes to cancer cell migration on collagen. Xu, X., Wang, Y., Chen, Z., Sternlicht, M.D., Hidalgo, M., Steffensen, B. Cancer Res. (2005)
- Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion. Sato, H., Okada, Y., Seiki, M. Thromb. Haemost. (1997)
- Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. Aimes, R.T., Quigley, J.P. J. Biol. Chem. (1995)
- Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton. Tomasek, J.J., Halliday, N.L., Updike, D.L., Ahern-Moore, J.S., Vu, T.K., Liu, R.W., Howard, E.W. J. Biol. Chem. (1997)
- Furin directly cleaves proMMP-2 in the trans-Golgi network resulting in a nonfunctioning proteinase. Cao, J., Rehemtulla, A., Pavlaki, M., Kozarekar, P., Chiarelli, C. J. Biol. Chem. (2005)
- A gene delivery system activatable by disease-associated matrix metalloproteinases. Peng, K.W., Morling, F.J., Cosset, F.L., Murphy, G., Russell, S.J. Hum. Gene Ther. (1997)
- Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy. Noda, K., Ishida, S., Inoue, M., Obata, K., Oguchi, Y., Okada, Y., Ikeda, E. Invest. Ophthalmol. Vis. Sci. (2003)
- Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Gabison, E.E., Mourah, S., Steinfels, E., Yan, L., Hoang-Xuan, T., Watsky, M.A., De Wever, B., Calvo, F., Mauviel, A., Menashi, S. Am. J. Pathol. (2005)
- Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets. Radomski, A., Jurasz, P., Sanders, E.J., Overall, C.M., Bigg, H.F., Edwards, D.R., Radomski, M.W. Br. J. Pharmacol. (2002)
- Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. Pap, T., Shigeyama, Y., Kuchen, S., Fernihough, J.K., Simmen, B., Gay, R.E., Billingham, M., Gay, S. Arthritis Rheum. (2000)
- Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases. Miyamori, H., Takino, T., Kobayashi, Y., Tokai, H., Itoh, Y., Seiki, M., Sato, H. J. Biol. Chem. (2001)
- Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T lymphocytes upon alpha(4)beta(1)-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Yakubenko, V.P., Lobb, R.R., Plow, E.F., Ugarova, T.P. Exp. Cell Res. (2000)
- Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas. Munaut, C., Noël, A., Hougrand, O., Foidart, J.M., Boniver, J., Deprez, M. Int. J. Cancer (2003)
- Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. McQuibban, G.A., Gong, J.H., Tam, E.M., McCulloch, C.A., Clark-Lewis, I., Overall, C.M. Science (2000)
- The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. Lara-Pezzi, E., Gómez-Gaviro, M.V., Gálvez, B.G., Mira, E., Iñiguez, M.A., Fresno, M., Martínez-A, C., Arroyo, A.G., López-Cabrera, M. J. Clin. Invest. (2002)
- Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants. Marbaix, E., Donnez, J., Courtoy, P.J., Eeckhout, Y. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Evidence for altered balance between matrix metalloproteinases and their inhibitors in human aortic diseases. Knox, J.B., Sukhova, G.K., Whittemore, A.D., Libby, P. Circulation (1997)
- Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix. Collen, A., Hanemaaijer, R., Lupu, F., Quax, P.H., van Lent, N., Grimbergen, J., Peters, E., Koolwijk, P., van Hinsbergh, V.W. Blood (2003)
- Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Ferri, N., Carragher, N.O., Raines, E.W. Am. J. Pathol. (2004)
- Metalloproteinase expression and prognosis in soft tissue sarcomas. Benassi, M.S., Gamberi, G., Magagnoli, G., Molendini, L., Ragazzini, P., Merli, M., Chiesa, F., Balladelli, A., Manfrini, M., Bertoni, F., Mercuri, M., Picci, P. Ann. Oncol. (2001)