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Gene Review:

IPO11 - importin 11

Homo sapiens

Synonyms: Imp11, Importin-11, RANBP11, Ran-binding protein 11, RanBP11

Plafker, S.M. et al., Plafker, S.M. et al., Sommer, T. et al., Wang, W. et al.

Plafker, Macara,

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High impact information on IPO11

We identified importin-11 as a potential new human member of this family, on the basis of limited similarity to the Saccharomyces cerevisiae protein, Lph2p, and cloned the complete open reading frame [1].
Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11 [2].
Furthermore, in a transient transfection assay, the nuclear accumulation of rpL12 was increased by coexpressed importin 11, but not by other importins [2].
Synleurin gene (slrn) maps to human chromosome at 5q12 [3].
Recently, Plafker et al. reported that importin 11-dependent nuclear import of the ubiquitin-conjugating enzyme UbcM2 occurs only if the latter is charged with ubiquitin [4].

References

Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. Plafker, S.M., Macara, I.G. EMBO J. (2000) [Pubmed]
Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. Plafker, S.M., Macara, I.G. Mol. Cell. Biol. (2002) [Pubmed]
Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses. Wang, W., Yang, Y., Li, L., Shi, Y. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Pardon me--no access without ubiquitin. Sommer, T., Jarosch, E. Dev. Cell (2005) [Pubmed]

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AgaP_AGAP002970	Anopheles gambiae str. PEST
AT3G08960	Arabidopsis thaliana
IPO11	Bos taurus
IPO11	Canis lupus familiaris
zgc:91897	Danio rerio
Ranbp11	Drosophila melanogaster
LRRC70	Gallus gallus
IPO11	Macaca mulatta
MGG_00744	Magnaporthe oryzae 70-15
Ipo11	Mus musculus
NCU02069	Neurospora crassa OR74A
IPO11	Pan troglodytes
Ipo11	Rattus norvegicus
ipo11	Xenopus (Silurana) tropicalis

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