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Gene Review

VRK3  -  vaccinia related kinase 3

Homo sapiens

Synonyms: Inactive serine/threonine-protein kinase VRK3, Serine/threonine-protein pseudokinase VRK3, Vaccinia-related kinase 3
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Disease relevance of VRK3

  • Here, we show that VRK3 suppresses ERK activity through direct binding to one of the MKPs, vaccinia H1-related (VHR), which specifically dephosphorylates and inactivates ERK in the nucleus [1].

High impact information on VRK3

  • This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3 [2].
  • The VRK3 proteins have key amino acid substitutions that disrupt invariant motifs required for catalytic activity, rendering them enzymatically inert [2].
  • VRK2 is expressed at lower levels than VRK1 and VRK3 in the mouse embryo [3].


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