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Gene Review

VRK2  -  vaccinia related kinase 2

Homo sapiens

Synonyms: Serine/threonine-protein kinase VRK2, Vaccinia-related kinase 2
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Disease relevance of VRK2


High impact information on VRK2


Chemical compound and disease context of VRK2


Biological context of VRK2

  • Endogenous human vacinia-related kinase 2 (VRK2) protein is present in both the nucleus and the cytosol, which is a consequence of alternative splicing of two VRK2 messages coding for proteins of 508 and 397 amino acids, respectively [4].

Anatomical context of VRK2


Enzymatic interactions of VRK2

  • Both VRK2 isoforms have an identical catalytic N-terminal domain and phosphorylate p53 in vitro uniquely in Thr18 [4].


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