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Gene Review

TRIM33  -  tripartite motif containing 33

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase TRIM33, ECTO, Ectodermin homolog, FLJ11429, KIAA1113, ...
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High impact information on TRIM33

  • All KRAB variants were shown, (i) to repress transcription when targeted to DNA through fusion to a heterologous DNA-binding domain in mammalian cells, and (ii) to interact specifically with TIF1 beta, but not with TIF1 alpha or TIF1 gamma [1].
  • In two cases, the RET rearrangements PTC6 and PTC7 were identified and assigned to balanced translocations t(7;10)(q32;q11.2) and t(1;10)(p13;q11.2), respectively [2].
  • Human transcriptional intermediary factor 1 gamma (Tif1gamma), also known as Ret fused gene 7 (RFG7), is a member of a novel family of transcriptional coregulator-encoding genes which function in cell differentiation and development [3].


  1. Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 beta. Abrink, M., Ortiz, J.A., Mark, C., Sanchez, C., Looman, C., Hellman, L., Chambon, P., Losson, R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma. Salassidis, K., Bruch, J., Zitzelsberger, H., Lengfelder, E., Kellerer, A.M., Bauchinger, M. Cancer Res. (2000) [Pubmed]
  3. Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene. Yan, K.P., Dollé, P., Mark, M., Lerouge, T., Wendling, O., Chambon, P., Losson, R. Gene (2004) [Pubmed]
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