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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Differentiation

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Disease relevance of Cell Differentiation


Psychiatry related information on Cell Differentiation

  • Because of the central role of cAMP to control cell differentiation, we examined the dose dependence, tissue selectivity, and critical periods involved in glucocorticoid regulation of fetal intracellular signaling mediated by adenylate cyclase [6].

High impact information on Cell Differentiation


Chemical compound and disease context of Cell Differentiation


Biological context of Cell Differentiation


Anatomical context of Cell Differentiation


Associations of Cell Differentiation with chemical compounds


Gene context of Cell Differentiation

  • Our results imply that Sox9 plays an essential role in sex determination, possibly immediately downstream of Sry in mammals, and that it functions as a critical Sertoli cell differentiation factor, perhaps in all vertebrates [32].
  • Pbx1-/- embryos had pancreatic hypoplasia and marked defects in exocrine and endocrine cell differentiation prior to death at embryonic day (E) 15 or E16 [18].
  • These findings suggest that unc-86 encodes a transcription factor, and that the related mammalian transcription factors may function to control cell fates and cell differentiation [20].
  • The putative coding sequence of mec-3 contains a homeobox, suggesting that the mec-3 protein specifies the expression of touch cell differentiation by binding to DNA and regulating transcription of genes that encode the differentiated features of these cells [33].
  • Id proteins may control cell differentiation by interfering with DNA binding of transcription factors [34].

Analytical, diagnostic and therapeutic context of Cell Differentiation


  1. Induction of cell differentiation by human immunodeficiency virus 1 vpr. Levy, D.N., Fernandes, L.S., Williams, W.V., Weiner, D.B. Cell (1993) [Pubmed]
  2. Possible role of retinoic acid binding protein in retinoid stimulation of embryonal carcinoma cell differentiation. Jetten, A.M., Jetten, M.E. Nature (1979) [Pubmed]
  3. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Zhang, P., Liégeois, N.J., Wong, C., Finegold, M., Hou, H., Thompson, J.C., Silverman, A., Harper, J.W., DePinho, R.A., Elledge, S.J. Nature (1997) [Pubmed]
  4. Chondroitin sulfate as a regulator of neuronal patterning in the retina. Brittis, P.A., Canning, D.R., Silver, J. Science (1992) [Pubmed]
  5. Adoptive transfer of human lymphoid cells to severely immunodeficient mice: models for normal human immune function, autoimmunity, lymphomagenesis, and AIDS. Mosier, D.E. Adv. Immunol. (1991) [Pubmed]
  6. Glucocorticoids enhance intracellular signaling via adenylate cyclase at three distinct loci in the fetus: a mechanism for heterologous teratogenic sensitization? Slotkin, T.A., Lau, C., McCook, E.C., Lappi, S.E., Seidler, F.J. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  7. Control of developmental regulators by Polycomb in human embryonic stem cells. Lee, T.I., Jenner, R.G., Boyer, L.A., Guenther, M.G., Levine, S.S., Kumar, R.M., Chevalier, B., Johnstone, S.E., Cole, M.F., Isono, K., Koseki, H., Fuchikami, T., Abe, K., Murray, H.L., Zucker, J.P., Yuan, B., Bell, G.W., Herbolsheimer, E., Hannett, N.M., Sun, K., Odom, D.T., Otte, A.P., Volkert, T.L., Bartel, D.P., Melton, D.A., Gifford, D.K., Jaenisch, R., Young, R.A. Cell (2006) [Pubmed]
  8. Identification of intrinsic determinants of midbrain dopamine neurons. Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T., Ericson, J. Cell (2006) [Pubmed]
  9. Homeobox galore: when reproduction goes RHOX and roll. Hogeveen, K.N., Sassone-Corsi, P. Cell (2005) [Pubmed]
  10. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Kim, M.J., Park, B.J., Kang, Y.S., Kim, H.J., Park, J.H., Kang, J.W., Lee, S.W., Han, J.M., Lee, H.W., Kim, S. Nat. Genet. (2003) [Pubmed]
  11. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Rutsch, F., Ruf, N., Vaingankar, S., Toliat, M.R., Suk, A., Höhne, W., Schauer, G., Lehmann, M., Roscioli, T., Schnabel, D., Epplen, J.T., Knisely, A., Superti-Furga, A., McGill, J., Filippone, M., Sinaiko, A.R., Vallance, H., Hinrichs, B., Smith, W., Ferre, M., Terkeltaub, R., Nürnberg, P. Nat. Genet. (2003) [Pubmed]
  12. Degradation of G alpha by the N-end rule pathway. Madura, K., Varshavsky, A. Science (1994) [Pubmed]
  13. Analysis of the calcium-modulated proteins, S100 and calmodulin, and their target proteins during C6 glioma cell differentiation. Zimmer, D.B., Van Eldik, L.J. J. Cell Biol. (1989) [Pubmed]
  14. Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation. Melloni, E., Pontremoli, S., Michetti, M., Sacco, O., Cakiroglu, A.G., Jackson, J.F., Rifkind, R.A., Marks, P.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  15. 4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors. Achkar, C.C., Derguini, F., Blumberg, B., Langston, A., Levin, A.A., Speck, J., Evans, R.M., Bolado, J., Nakanishi, K., Buck, J., Gudas, L.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  16. A nonsense mutation of the human luteinizing hormone receptor gene in Leydig cell hypoplasia. Laue, L., Wu, S.M., Kudo, M., Hsueh, A.J., Cutler, G.B., Griffin, J.E., Wilson, J.D., Brain, C., Berry, A.C., Grant, D.B. Hum. Mol. Genet. (1995) [Pubmed]
  17. An intramolecular SH3-domain interaction regulates c-Abl activity. Barilá, D., Superti-Furga, G. Nat. Genet. (1998) [Pubmed]
  18. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Kim, S.K., Selleri, L., Lee, J.S., Zhang, A.Y., Gu, X., Jacobs, Y., Cleary, M.L. Nat. Genet. (2002) [Pubmed]
  19. Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox. Costa, M., Weir, M., Coulson, A., Sulston, J., Kenyon, C. Cell (1988) [Pubmed]
  20. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Finney, M., Ruvkun, G., Horvitz, H.R. Cell (1988) [Pubmed]
  21. A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology. Barolo, S., Walker, R.G., Polyanovsky, A.D., Freschi, G., Keil, T., Posakony, J.W. Cell (2000) [Pubmed]
  22. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Li, H., Arber, S., Jessell, T.M., Edlund, H. Nat. Genet. (1999) [Pubmed]
  23. Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Sandgren, E.P., Luetteke, N.C., Palmiter, R.D., Brinster, R.L., Lee, D.C. Cell (1990) [Pubmed]
  24. Control of lysozyme induction in the differentiation of myeloid leukemic cells. Krystosek, A., Sachs, L. Cell (1976) [Pubmed]
  25. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Li, S., Li, Y., Carthew, R.W., Lai, Z.C. Cell (1997) [Pubmed]
  26. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Pfaff, S.L., Mendelsohn, M., Stewart, C.L., Edlund, T., Jessell, T.M. Cell (1996) [Pubmed]
  27. Glycogen synthase kinase 3 regulates cell fate in Dictyostelium. Harwood, A.J., Plyte, S.E., Woodgett, J., Strutt, H., Kay, R.R. Cell (1995) [Pubmed]
  28. An early decrease in phosphatidylinositol turnover occurs on induction of Friend cell differentiation and precedes the decrease in c-myc expression. Faletto, D.L., Arrow, A.S., Macara, I.G. Cell (1985) [Pubmed]
  29. Polarizing activity and retinoid synthesis in the floor plate of the neural tube. Wagner, M., Thaller, C., Jessell, T., Eichele, G. Nature (1990) [Pubmed]
  30. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. de Thé, H., Chomienne, C., Lanotte, M., Degos, L., Dejean, A. Nature (1990) [Pubmed]
  31. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Bohl, D., Naffakh, N., Heard, J.M. Nat. Med. (1997) [Pubmed]
  32. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Morais da Silva, S., Hacker, A., Harley, V., Goodfellow, P., Swain, A., Lovell-Badge, R. Nat. Genet. (1996) [Pubmed]
  33. mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Way, J.C., Chalfie, M. Cell (1988) [Pubmed]
  34. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Lyden, D., Young, A.Z., Zagzag, D., Yan, W., Gerald, W., O'Reilly, R., Bader, B.L., Hynes, R.O., Zhuang, Y., Manova, K., Benezra, R. Nature (1999) [Pubmed]
  35. Inducers of mammalian cell differentiation stimulate dome formation in a differentiated kidney epithelial cell line (MDCK). Lever, J.E. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  36. A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens. Wistow, G.J., Shaughnessy, M.P., Lee, D.C., Hodin, J., Zelenka, P.S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  37. Differentiation of human prostate cancer PC-3 cells induced by inhibitors of inosine 5'-monophosphate dehydrogenase. Floryk, D., Tollaksen, S.L., Giometti, C.S., Huberman, E. Cancer Res. (2004) [Pubmed]
  38. Overexpression of dihydrodiol dehydrogenase as a prognostic marker of non-small cell lung cancer. Hsu, N.Y., Ho, H.C., Chow, K.C., Lin, T.Y., Shih, C.S., Wang, L.S., Tsai, C.M. Cancer Res. (2001) [Pubmed]
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