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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CDK12  -  cyclin-dependent kinase 12

Homo sapiens

Synonyms: CDC2-related protein kinase 7, CRK7, CRKR, CRKRS, Cdc2-related kinase, arginine/serine-rich, ...
 
 
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High impact information on CRKRS

  • CrkRS is a Cdc2-related protein kinase that contains an arginine- and serine-rich (SR) domain, a characteristic of the SR protein family of splicing factors, and is proposed to be involved in RNA processing [1].
  • CrkRS has extensive proline-rich regions that match the consensus for SH3 and WW domain binding sites, and an RS domain that is predominantly found in splicing factors [2].
  • Like RNA polymerase II, CrkRS is a constitutive MPM-2 antigen throughout the cell cycle [2].

References

  1. Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation. Chen, H.H., Wang, Y.C., Fann, M.J. Mol. Cell. Biol. (2006) [Pubmed]
  2. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. Ko, T.K., Kelly, E., Pines, J. J. Cell. Sci. (2001) [Pubmed]
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