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Gene Review:

PGA5 - pepsinogen 5, group I (pepsinogen A)

Homo sapiens

Taggart, R.T. et al., Taggart, R.T. et al., Nakai, H. et al., Bank, R.A. et al.

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High impact information on PGA5

We propose that the alpha- and beta-subclasses contain net charge amino acid substitutions encoded by the corresponding pepsinogen genes: PGA3, PGA4, and PGA5 [1].
PGA-5 showed a peak strongly absorbing at 254 nm absent in PGA-3 [2].

Biological context of PGA5

The genes coding for human pepsinogen (PGA3, PGA4, and PGA5) were assigned to chromosome region 11q13 by in situ hybridization [3].
Here, we describe the interrelationships between the most common pepsinogen protein phenotypes and the corresponding pepsinogen haplotypes (A, B, and C) containing different combinations of the PGA3, PGA4, and PGA5 genes [4].

References

Immunochemical, electrophoretic, and genetic heterogeneity of pepsinogen I. Characterization with monoclonal antibodies. Taggart, R.T., Samloff, I.M. Gastroenterology (1987) [Pubmed]
Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C. Bank, R.A., Crusius, B.C., Zwiers, T., Meuwissen, S.G., Arwert, F., Pronk, J.C. FEBS Lett. (1988) [Pubmed]
Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization. Nakai, H., Byers, M.G., Shows, T.B., Taggart, R.T. Cytogenet. Cell Genet. (1986) [Pubmed]
Relationships between the human pepsinogen DNA and protein polymorphisms. Taggart, R.T., Samloff, I.M., Raffel, L.J., Graham, A., Cass, C., Petersen, G.M., Rotter, J.I., Skolnick, M.H., Schwartz, C.E., Bell, G.I. Am. J. Hum. Genet. (1986) [Pubmed]

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PGA5	Bos taurus
PGA	Canis lupus familiaris
LOC395926	Gallus gallus
PGA3	Homo sapiens
PGA4	Homo sapiens
PGA4	Macaca mulatta
LOC101058771	Pan troglodytes
pga4	Xenopus (Silurana) tropicalis

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