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Gene Review

ATP6V1B2  -  ATPase, H+ transporting, lysosomal...

Homo sapiens

Synonyms: ATP6B1B2, ATP6B2, Endomembrane proton pump 58 kDa subunit, HO57, V-ATPase subunit B 2, ...
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High impact information on ATP6V1B2

  • Furthermore, we show by in situ hybridization that HO57 is the only isoform that is exclusively and highly expressed by osteoclasts [1].
  • Here we describe the cloning and characterization of a cDNA isoform of subunit B, HO57, from an osteoclastoma cDNA library [1].
  • In cells lacking V(0) genes, Vma2p and Vma5p were still detected on Vid vesicles and vacuoles, suggesting that the distribution of V(1) proteins is independent of V(0) genes [2].


  1. Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms. van Hille, B., Richener, H., Schmid, P., Puettner, I., Green, J.R., Bilbe, G. Biochem. J. (1994) [Pubmed]
  2. Degradation of the Gluconeogenic Enzyme Fructose-1, 6-Bisphosphatase is Dependent on the Vacuolar ATPase. Liu, J., Brown, C.R., Chiang, H.L. Autophagy. (2005) [Pubmed]
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