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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Library

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Disease relevance of Gene Library


Psychiatry related information on Gene Library


High impact information on Gene Library

  • Using a fucose-specific, lectin-staining procedure for detection of fucosylated glycoproteins and a retroviral cDNA library, we isolated a cDNA complementing the fucosylation defect in the patient's fibroblasts [7].
  • Growth/differentiation factor-1 (Gdf-1, encoded by Gdf1) is a TGF-beta family member of unknown function that was originally isolated from an early mouse embryo cDNA library and is expressed specifically in the nervous systemin late-stage embryos and adult mice [8].
  • We identified this gene (USH1C), encoding a PDZ-domain-containing protein, harmonin, in a subtracted mouse cDNA library derived from inner ear sensory areas [9].
  • A lambda gt11 cDNA library screen for proteins that interact with SopE identified Rac-1 and CDC42 [10].
  • Differential screening of cDNA libraries constructed from individual rat VNO neurons has led to the isolation of a novel family of approximately 100 genes encoding seven transmembrane receptors with sequence similarity with Ca2+-sensing and metabotropic glutamate receptors [11].

Chemical compound and disease context of Gene Library


Biological context of Gene Library

  • DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library [17].
  • We have isolated a multigene family, tctex-1, by screening a testicular cell cDNA library with two reciprocally subtracted testicular cDNA probes [18].
  • We have now determined the partial amino-acid sequence of the purified G-CSF protein, and by using oligonucleotides as probes, have isolated several clones containing G-CSF complementary DNA from the cDNA library prepared with messenger RNA from CHU-2 cells [19].
  • Here we use these fragments to screen human complementary DNA libraries to show that the translocation alters the open reading frame of an expressed gene on chromosome 22 gene by substituting a sequence encoding a putative RNA-binding domain for that of the DNA-binding domain of the human homologue of murine Fli-1 [20].
  • A complementary DNA encoding a pollen allergen from white birch (Betula verrucosa) that was isolated from a pollen complementary DNA library with serum immunoglobulin E from a birch pollen-allergic individual revealed significant sequence homology to profilins [21].

Anatomical context of Gene Library


Associations of Gene Library with chemical compounds

  • Using as probe a cDNA encoding the rat brain glucose transporter, we isolated from a rat liver cDNA library a clone encoding a protein 55% identical in sequence to the rat brain transporter, and with a superimpossible hydropathy plot [27].
  • We have now isolated from a rat genomic DNA library a segment of a DNA encoding most of POMC, using as probe a mouse 144-base pair cloned cDNA fragment encoding beta-MSH and beta-endorphin [28].
  • Differential hybridization was used to screen a complementary DNA library constructed from PC12 cells treated with NGF and cycloheximide [29].
  • Complementary DNA (cDNA) libraries were constructed from frog skin messenger RNA and screened with a mixture of oligonucleotides that contained the codons complementary to five amino acids of dermorphin [30].
  • To address these questions, cDNA libraries were constructed from freshly isolated rat peritoneal MCs and from the rat mucosal MC line RBL-1. cDNA clones for 10 different serine proteases (RMCP-1-10), and the MC carboxypeptidase A were isolated and characterized [31].

Gene context of Gene Library

  • Three members of the Jun/AP-1 family have been identified in mouse cDNA libraries: c-Jun, Jun-B, and Jun-D [32].
  • A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library [33].
  • Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library [34].
  • We have adopted an alternative approach which relies on differential screening of an organized subtracted cDNA library from activated peripheral blood mononuclear cells, using the inducibility of lymphokine messenger RNAs by anti-CD28 as a primary screening criterion [35].
  • We have now screened complementary DNA libraries constructed from peripheral tissues to determine whether the messenger RNA encoding APP in these tissues is identical to that expressed in brain, and we identify a second APP mRNA that encodes an additional internal domain with a sequence characteristic of a Kunitz-type serine protease inhibitor [36].

Analytical, diagnostic and therapeutic context of Gene Library


  1. Isolation of a partial candidate gene for Menkes disease by positional cloning. Mercer, J.F., Livingston, J., Hall, B., Paynter, J.A., Begy, C., Chandrasekharappa, S., Lockhart, P., Grimes, A., Bhave, M., Siemieniak, D. Nat. Genet. (1993) [Pubmed]
  2. Human D-type cyclin. Xiong, Y., Connolly, T., Futcher, B., Beach, D. Cell (1991) [Pubmed]
  3. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Chabas, D., Baranzini, S.E., Mitchell, D., Bernard, C.C., Rittling, S.R., Denhardt, D.T., Sobel, R.A., Lock, C., Karpuj, M., Pedotti, R., Heller, R., Oksenberg, J.R., Steinman, L. Science (2001) [Pubmed]
  4. Terminal proteins essential for the replication of linear plasmids and chromosomes in Streptomyces. Bao, K., Cohen, S.N. Genes Dev. (2001) [Pubmed]
  5. A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. Robbins, P.F., El-Gamil, M., Li, Y.F., Kawakami, Y., Loftus, D., Appella, E., Rosenberg, S.A. J. Exp. Med. (1996) [Pubmed]
  6. Mechanisms that generate human immunoglobulin diversity operate from the 8th week of gestation in fetal liver. Cuisinier, A.M., Gauthier, L., Boubli, L., Fougereau, M., Tonnelle, C. Eur. J. Immunol. (1993) [Pubmed]
  7. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Lübke, T., Marquardt, T., Etzioni, A., Hartmann, E., von Figura, K., Körner, C. Nat. Genet. (2001) [Pubmed]
  8. Regulation of left-right patterning in mice by growth/differentiation factor-1. Rankin, C.T., Bunton, T., Lawler, A.M., Lee, S.J. Nat. Genet. (2000) [Pubmed]
  9. A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C. Verpy, E., Leibovici, M., Zwaenepoel, I., Liu, X.Z., Gal, A., Salem, N., Mansour, A., Blanchard, S., Kobayashi, I., Keats, B.J., Slim, R., Petit, C. Nat. Genet. (2000) [Pubmed]
  10. S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Hardt, W.D., Chen, L.M., Schuebel, K.E., Bustelo, X.R., Galán, J.E. Cell (1998) [Pubmed]
  11. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Herrada, G., Dulac, C. Cell (1997) [Pubmed]
  12. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Birnbaum, M.J., Haspel, H.C., Rosen, O.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  13. The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus. Walker, K., Long, R., Croteau, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  14. Cloning of the human estrogen receptor cDNA. Walter, P., Green, S., Greene, G., Krust, A., Bornert, J.M., Jeltsch, J.M., Staub, A., Jensen, E., Scrace, G., Waterfield, M. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  15. Molecular cloning of matrix Gla protein: implications for substrate recognition by the vitamin K-dependent gamma-carboxylase. Price, P.A., Fraser, J.D., Metz-Virca, G. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  16. Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichia coli: antibodies for orotate decarboxylation. Smiley, J.A., Benkovic, S.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. A nonpolymorphic class I gene in the murine major histocompatibility complex. Mellor, A.L., Weiss, E.H., Kress, M., Jay, G., Flavell, R.A. Cell (1984) [Pubmed]
  18. tctex-1: a candidate gene family for a mouse t complex sterility locus. Lader, E., Ha, H.S., O'Neill, M., Artzt, K., Bennett, D. Cell (1989) [Pubmed]
  19. Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H. Nature (1986) [Pubmed]
  20. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G. Nature (1992) [Pubmed]
  21. Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Valenta, R., Duchêne, M., Pettenburger, K., Sillaber, C., Valent, P., Bettelheim, P., Breitenbach, M., Rumpold, H., Kraft, D., Scheiner, O. Science (1991) [Pubmed]
  22. Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cochran, B.H., Reffel, A.C., Stiles, C.D. Cell (1983) [Pubmed]
  23. Isolation of a candidate gene for Norrie disease by positional cloning. Berger, W., Meindl, A., van de Pol, T.J., Cremers, F.P., Ropers, H.H., Döerner, C., Monaco, A., Bergen, A.A., Lebo, R., Warburg, M. Nat. Genet. (1992) [Pubmed]
  24. Cloning by functional expression of a member of the glutamate receptor family. Hollmann, M., O'Shea-Greenfield, A., Rogers, S.W., Heinemann, S. Nature (1989) [Pubmed]
  25. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Wong, F.S., Karttunen, J., Dumont, C., Wen, L., Visintin, I., Pilip, I.M., Shastri, N., Pamer, E.G., Janeway, C.A. Nat. Med. (1999) [Pubmed]
  26. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Chang, C.S., Kokontis, J., Liao, S.T. Science (1988) [Pubmed]
  27. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Thorens, B., Sarkar, H.K., Kaback, H.R., Lodish, H.F. Cell (1988) [Pubmed]
  28. Most of the coding region of rat ACTH beta--LPH precursor gene lacks intervening sequences. Drouin, J., Goodman, H.M. Nature (1980) [Pubmed]
  29. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Milbrandt, J. Science (1987) [Pubmed]
  30. D-alanine in the frog skin peptide dermorphin is derived from L-alanine in the precursor. Richter, K., Egger, R., Kreil, G. Science (1987) [Pubmed]
  31. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lützelschwab, C., Pejler, G., Aveskogh, M., Hellman, L. J. Exp. Med. (1997) [Pubmed]
  32. DNA binding activities of three murine Jun proteins: stimulation by Fos. Nakabeppu, Y., Ryder, K., Nathans, D. Cell (1988) [Pubmed]
  33. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Chavrier, P., Parton, R.G., Hauri, H.P., Simons, K., Zerial, M. Cell (1990) [Pubmed]
  34. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. March, C.J., Mosley, B., Larsen, A., Cerretti, D.P., Braedt, G., Price, V., Gillis, S., Henney, C.S., Kronheim, S.R., Grabstein, K. Nature (1985) [Pubmed]
  35. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Minty, A., Chalon, P., Derocq, J.M., Dumont, X., Guillemot, J.C., Kaghad, M., Labit, C., Leplatois, P., Liauzun, P., Miloux, B. Nature (1993) [Pubmed]
  36. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Tanzi, R.E., McClatchey, A.I., Lamperti, E.D., Villa-Komaroff, L., Gusella, J.F., Neve, R.L. Nature (1988) [Pubmed]
  37. Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice. Mercer, J.F., Grimes, A., Ambrosini, L., Lockhart, P., Paynter, J.A., Dierick, H., Glover, T.W. Nat. Genet. (1994) [Pubmed]
  38. Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Mitchell, P.J., Timmons, P.M., Hébert, J.M., Rigby, P.W., Tjian, R. Genes Dev. (1991) [Pubmed]
  39. Identification and upregulation of galactose/N-acetylgalactosamine macrophage lectin in rat cardiac allografts with arteriosclerosis. Russell, M.E., Utans, U., Wallace, A.F., Liang, P., Arceci, R.J., Karnovsky, M.J., Wyner, L.R., Yamashita, Y., Tarn, C. J. Clin. Invest. (1994) [Pubmed]
  40. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. Pradet-Balade, B., Medema, J.P., López-Fraga, M., Lozano, J.C., Kolfschoten, G.M., Picard, A., Martínez-A, C., Garcia-Sanz, J.A., Hahne, M. EMBO J. (2002) [Pubmed]
  41. Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos. Abe, K., Wei, J.F., Wei, F.S., Hsu, Y.C., Uehara, H., Artzt, K., Bennett, D. EMBO J. (1988) [Pubmed]
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