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Gene Review:

Lair1 - leukocyte-associated Ig-like receptor 1

Mus musculus

Synonyms: 5133400O11Rik, BB115266, D7Bwg0421e, LAIR-1, Lair-1, ...

Sathish, J.G. et al., Maasho, K. et al., Verbrugge, A. et al., Verbrugge, A. et al.

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High impact information on Lair1

From this yeast tri-hybrid screen, the p85beta subunit of phosphatidylinositol 3-kinase and the immunoreceptor tyrosine-based inhibitory motif-containing receptors, leukocyte-associated Ig-like receptor-1 (LAIR-1) and programmed death-1 (PD-1), were identified [1].
Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase [2].
Leukocyte-associated Ig-like receptor (LAIR)-1 is an inhibitory receptor expressed on most human leukocytes [3].
The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation [4].

References

Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells. Sathish, J.G., Johnson, K.G., Fuller, K.J., LeRoy, F.G., Meyaard, L., Sims, M.J., Matthews, R.J. J. Immunol. (2001) [Pubmed]
Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase. Verbrugge, A., Rijkers, E.S., de Ruiter, T., Meyaard, L. Eur. J. Immunol. (2006) [Pubmed]
Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment. Verbrugge, A., Ruiter Td, T., Clevers, H., Meyaard, L. Int. Immunol. (2003) [Pubmed]
The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation. Maasho, K., Masilamani, M., Valas, R., Basu, S., Coligan, J.E., Borrego, F. Mol. Immunol. (2005) [Pubmed]

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LAIR1	Bos taurus
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LAIR1	Homo sapiens
LAIR1	Macaca mulatta
LAIR1	Pan troglodytes
Lair1	Rattus norvegicus

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