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Gene Review

POLR2K  -  polymerase (RNA) II (DNA directed)...

Homo sapiens

Synonyms: ABC10-alpha, DNA-directed RNA polymerase II subunit K, DNA-directed RNA polymerases I, II, and III subunit RPABC4, RNA polymerase II 7.0 kDa subunit, RNA polymerases I, II, and III subunit ABC4, ...
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High impact information on POLR2K

  • Excess purified Pol II subunits hRPB2 or hRPB10alpha blocked BRCA1- and VP16-dependent transcriptional activation in vitro with minimal effect on basal transcription [1].
  • In this study, we demonstrate that two of the subunits, hRPB2 and hRPB10alpha, mediate the regulated stimulation of transcription [1].
  • Further analysis of binding specificities showed that spTFIIEbeta binds the Rpb2 and Rpb12 subunits of PolII, whereas spTFIIEalpha predominantly binds Rpb5, which is located at the clamp region and changes conformation upon transcription initiation [2].


  1. BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10alpha in activated transcription. Schlegel, B.P., Green, V.J., Ladias, J.A., Parvin, J.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Studies of Schizosaccharomyces pombe TFIIE indicate conformational and functional changes in RNA polymerase II at transcription initiation. Hayashi, K., Watanabe, T., Tanaka, A., Furumoto, T., Sato-Tsuchiya, C., Kimura, M., Yokoi, M., Ishihama, A., Hanaoka, F., Ohkuma, Y. Genes Cells (2005) [Pubmed]
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