Gene Review:
BRCA1 - breast cancer 1, early onset
Homo sapiens
Synonyms:
BRCAI, BRCC1, BROVCA1, Breast cancer type 1 susceptibility protein, FANCS, ...
- BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Hartman, A.R., Ford, J.M. Nat. Genet. (2002)
- BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Bochar, D.A., Wang, L., Beniya, H., Kinev, A., Xue, Y., Lane, W.S., Wang, W., Kashanchi, F., Shiekhattar, R. Cell (2000)
- Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Meijers-Heijboer, H., van den Ouweland, A., Klijn, J., Wasielewski, M., de Snoo, A., Oldenburg, R., Hollestelle, A., Houben, M., Crepin, E., van Veghel-Plandsoen, M., Elstrodt, F., van Duijn, C., Bartels, C., Meijers, C., Schutte, M., McGuffog, L., Thompson, D., Easton, D., Sodha, N., Seal, S., Barfoot, R., Mangion, J., Chang-Claude, J., Eccles, D., Eeles, R., Evans, D.G., Houlston, R., Murday, V., Narod, S., Peretz, T., Peto, J., Phelan, C., Zhang, H.X., Szabo, C., Devilee, P., Goldgar, D., Futreal, P.A., Nathanson, K.L., Weber, B., Rahman, N., Stratton, M.R. Nat. Genet. (2002)
- The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. Bridge, W.L., Vandenberg, C.J., Franklin, R.J., Hiom, K. Nat. Genet. (2005)
- Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Li, S., Ting, N.S., Zheng, L., Chen, P.L., Ziv, Y., Shiloh, Y., Lee, E.Y., Lee, W.H. Nature (2000)
- BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy. Quinn, J.E., James, C.R., Stewart, G.E., Mulligan, J.M., White, P., Chang, G.K., Mullan, P.B., Johnston, P.G., Wilson, R.H., Harkin, D.P. Clin. Cancer Res. (2007)
- Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. Schayek, H., Haugk, K., Sun, S., True, L.D., Plymate, S.R., Werner, H. Clin. Cancer Res. (2009)
- A high proportion of DNA variants of BRCA1 and BRCA2 is associated with aberrant splicing in breast/ovarian cancer patients. Sanz, D.J., Acedo, A., Infante, M., Durán, M., Pérez-Cabornero, L., Esteban-Cardeñosa, E., Lastra, E., Pagani, F., Miner, C., Velasco, E.A. Clin. Cancer Res. (2010)
- Clinical management of women with genomic BRCA1 and BRCA2 mutations. Chang, J., Elledge, R.M. Breast Cancer Res. Treat. (2001)
- Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. Trenz, K., Rothfuss, A., Schütz, P., Speit, G. Mutat. Res. (2002)
- BRCA1 and BRCA2 gene mutations: decision-making dilemmas concerning testing and management. Fasouliotis, S.J., Schenker, J.G. Obstetrical & gynecological survey. (2000)
- BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes. Lerman, C., Narod, S., Schulman, K., Hughes, C., Gomez-Caminero, A., Bonney, G., Gold, K., Trock, B., Main, D., Lynch, J., Fulmore, C., Snyder, C., Lemon, S.J., Conway, T., Tonin, P., Lenoir, G., Lynch, H. JAMA (1996)
- Predictors of participation in psychosocial telephone counseling following genetic testing for BRCA1 and BRCA2 mutations. Halbert, C.H., Wenzel, L., Lerman, C., Peshkin, B.N., Narod, S., Marcus, A., Corio, C., Demarco, T., Bellamy, S. Cancer Epidemiol. Biomarkers Prev. (2004)
- Epithelial ovarian cancer: prevention, diagnosis, and treatment. Partridge, E.E., Barnes, M.N. CA: a cancer journal for clinicians. (1999)
- The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Levran, O., Attwooll, C., Henry, R.T., Milton, K.L., Neveling, K., Rio, P., Batish, S.D., Kalb, R., Velleuer, E., Barral, S., Ott, J., Petrini, J., Schindler, D., Hanenberg, H., Auerbach, A.D. Nat. Genet. (2005)
- X-linked inheritance of Fanconi anemia complementation group B. Meetei, A.R., Levitus, M., Xue, Y., Medhurst, A.L., Zwaan, M., Ling, C., Rooimans, M.A., Bier, P., Hoatlin, M., Pals, G., de Winter, J.P., Wang, W., Joenje, H. Nat. Genet. (2004)
- BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Yarden, R.I., Pardo-Reoyo, S., Sgagias, M., Cowan, K.H., Brody, L.C. Nat. Genet. (2002)
- BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. Razandi, M., Pedram, A., Rosen, E.M., Levin, E.R. Mol. Cell. Biol. (2004)
- Loss of coordinated androgen regulation in nonmalignant ovarian epithelial cells with BRCA1/2 mutations and ovarian cancer cells. Evangelou, A., Letarte, M., Jurisica, I., Sultan, M., Murphy, K.J., Rosen, B., Brown, T.J. Cancer Res. (2003)
- Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers. Kadouri, L., Kote-Jarai, Z., Easton, D.F., Hubert, A., Hamoudi, R., Glaser, B., Abeliovich, D., Peretz, T., Eeles, R.A. Int. J. Cancer (2004)
- Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells. Gao, B., Shen, X., Kunos, G., Meng, Q., Goldberg, I.D., Rosen, E.M., Fan, S. FEBS Lett. (2001)
- hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Lee, J.S., Collins, K.M., Brown, A.L., Lee, C.H., Chung, J.H. Nature (2000)
- BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Welcsh, P.L., Lee, M.K., Gonzalez-Hernandez, R.M., Black, D.J., Mahadevappa, M., Swisher, E.M., Warrington, J.A., King, M.C. Proc. Natl. Acad. Sci. U.S.A. (2002)
- A somatic cell hybrid map of the long arm of human chromosome 17, containing the familial breast cancer locus (BRCA1). Black, D.M., Nicolai, H., Borrow, J., Solomon, E. Am. J. Hum. Genet. (1993)
- Inherited breast and ovarian cancer. Szabo, C.I., King, M.C. Hum. Mol. Genet. (1995)
- BRCA1 inhibition of telomerase activity in cultured cells. Xiong, J., Fan, S., Meng, Q., Schramm, L., Wang, C., Bouzahza, B., Zhou, J., Zafonte, B., Goldberg, I.D., Haddad, B.R., Pestell, R.G., Rosen, E.M. Mol. Cell. Biol. (2003)
- Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Zhong, Q., Chen, C.F., Li, S., Chen, Y., Wang, C.C., Xiao, J., Chen, P.L., Sharp, Z.D., Lee, W.H. Science (1999)
- Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Tibbetts, R.S., Cortez, D., Brumbaugh, K.M., Scully, R., Livingston, D., Elledge, S.J., Abraham, R.T. Genes Dev. (2000)
- Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. Franchitto, A., Pichierri, P. J. Cell Biol. (2002)
- A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Wang, R.H., Yu, H., Deng, C.X. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells. Lu, Y., Amleh, A., Sun, J., Jin, X., McCullough, S.D., Baer, R., Ren, D., Li, R., Hu, Y. Mol. Endocrinol. (2007)
- Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity. Ma, Y., Hu, C., Riegel, A.T., Fan, S., Rosen, E.M. Mol. Endocrinol. (2007)
- Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M.S., Timmers, C., Hejna, J., Grompe, M., D'Andrea, A.D. Mol. Cell (2001)
- Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex. Brzovic, P.S., Keeffe, J.R., Nishikawa, H., Miyamoto, K., Fox, D., Fukuda, M., Ohta, T., Klevit, R. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Ouchi, T., Lee, S.W., Ouchi, M., Aaronson, S.A., Horvath, C.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Chai, Y.L., Cui, J., Shao, N., Shyam, E., Reddy, P., Rao, V.N. Oncogene (1999)
- BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Ruffner, H., Jiang, W., Craig, A.G., Hunter, T., Verma, I.M. Mol. Cell. Biol. (1999)
- Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. Gatei, M., Zhou, B.B., Hobson, K., Scott, S., Young, D., Khanna, K.K. J. Biol. Chem. (2001)
- BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. Moreau, K., Dizin, E., Ray, H., Luquain, C., Lefai, E., Foufelle, F., Billaud, M., Lenoir, G.M., Venezia, N.D. J. Biol. Chem. (2006)
- Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Shiozaki, E.N., Gu, L., Yan, N., Shi, Y. Mol. Cell (2004)
- Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hussain, S., Wilson, J.B., Medhurst, A.L., Hejna, J., Witt, E., Ananth, S., Davies, A., Masson, J.Y., Moses, R., West, S.C., de Winter, J.P., Ashworth, A., Jones, N.J., Mathew, C.G. Hum. Mol. Genet. (2004)
- BRCA1 up-regulation is associated with repair-mediated resistance to cis-diamminedichloroplatinum(II). Husain, A., He, G., Venkatraman, E.S., Spriggs, D.R. Cancer Res. (1998)
- p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Fan, S., Ma, Y.X., Wang, C., Yuan, R.Q., Meng, Q., Wang, J.A., Erdos, M., Goldberg, I.D., Webb, P., Kushner, P.J., Pestell, R.G., Rosen, E.M. Cancer Res. (2002)
- Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Wang, H.C., Chou, W.C., Shieh, S.Y., Shen, C.Y. Cancer Res. (2006)
- Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor. Park, J.J., Irvine, R.A., Buchanan, G., Koh, S.S., Park, J.M., Tilley, W.D., Stallcup, M.R., Press, M.F., Coetzee, G.A. Cancer Res. (2000)
- BRCA1-induced apoptosis involves inactivation of ERK1/2 activities. Yan, Y., Haas, J.P., Kim, M., Sgagias, M.K., Cowan, K.H. J. Biol. Chem. (2002)
- Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. Lou, Z., Chini, C.C., Minter-Dykhouse, K., Chen, J. J. Biol. Chem. (2003)
- Mutation analysis in the BRCA2 gene in primary breast cancers. Miki, Y., Katagiri, T., Kasumi, F., Yoshimoto, T., Nakamura, Y. Nat. Genet. (1996)
- The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Kleiman, F.E., Manley, J.L. Cell (2001)
- A novel ubiquitin ligase is deficient in Fanconi anemia. Meetei, A.R., de Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., van de Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E., Hoatlin, M.E., Joenje, H., Wang, W. Nat. Genet. (2003)
- Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Alderton, G.K., Galbiati, L., Griffith, E., Surinya, K.H., Neitzel, H., Jackson, A.P., Jeggo, P.A., O'Driscoll, M. Nat. Cell Biol. (2006)
- A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. Foray, N., Marot, D., Gabriel, A., Randrianarison, V., Carr, A.M., Perricaudet, M., Ashworth, A., Jeggo, P. EMBO J. (2003)
- RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Martin, R.W., Orelli, B.J., Yamazoe, M., Minn, A.J., Takeda, S., Bishop, D.K. Cancer Res. (2007)
- Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells. Kehn, K., Berro, R., Alhaj, A., Bottazzi, M.E., Yeh, W.I., Klase, Z., Van Duyne, R., Fu, S., Kashanchi, F. Oncogene (2007)
- A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation. Li, W., Xiao, C., Vonderhaar, B.K., Deng, C.X. Oncogene (2007)
- THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21. Bowcock, A.M., Anderson, L.A., Friedman, L.S., Black, D.M., Osborne-Lawrence, S., Rowell, S.E., Hall, J.M., Solomon, E., King, M.C. Am. J. Hum. Genet. (1993)
- Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Ibanez de Caceres, I., Battagli, C., Esteller, M., Herman, J.G., Dulaimi, E., Edelson, M.I., Bergman, C., Ehya, H., Eisenberg, B.L., Cairns, P. Cancer Res. (2004)