The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

POLRMT  -  polymerase (RNA) mitochondrial (DNA directed)

Homo sapiens

Synonyms: APOLMT, DNA-directed RNA polymerase, mitochondrial, MTRNAP, MTRPOL, MtRPOL, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on POLRMT

  • The presence of two proteins that interact with mammalian POLRMT may allow flexible regulation of mtDNA gene expression in response to the complex physiological demands of mammalian metabolism [1].
  • Recently, the core human mitochondrial transcription machinery has been defined, comprising a bacteriophage-related mtRNA polymerase (POLRMT), an HMG-box transcription factor (h-mtTFA), and two transcription factors (h-mtTFB1 and h-mtTFB2) that also serve as rRNA methyltransferases [2].
 

Other interactions of POLRMT

  • Here we show that transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV). spRNAP-IV is expressed from an alternative transcript of the mitochondrial RNA polymerase gene (POLRMT) [3].

References

  1. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.G., Gustafsson, C.M. Nat. Genet. (2002) [Pubmed]
  2. Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Bonawitz, N.D., Clayton, D.A., Shadel, G.S. Mol. Cell (2006) [Pubmed]
  3. Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin. Kravchenko, J.E., Rogozin, I.B., Koonin, E.V., Chumakov, P.M. Nature (2005) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities