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Gene Review

POLRMT  -  polymerase (RNA) mitochondrial (DNA directed)

Homo sapiens

Synonyms: APOLMT, DNA-directed RNA polymerase, mitochondrial, MTRNAP, MTRPOL, MtRPOL, ...
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High impact information on POLRMT

  • The presence of two proteins that interact with mammalian POLRMT may allow flexible regulation of mtDNA gene expression in response to the complex physiological demands of mammalian metabolism [1].
  • Recently, the core human mitochondrial transcription machinery has been defined, comprising a bacteriophage-related mtRNA polymerase (POLRMT), an HMG-box transcription factor (h-mtTFA), and two transcription factors (h-mtTFB1 and h-mtTFB2) that also serve as rRNA methyltransferases [2].

Other interactions of POLRMT

  • Here we show that transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV). spRNAP-IV is expressed from an alternative transcript of the mitochondrial RNA polymerase gene (POLRMT) [3].


  1. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.G., Gustafsson, C.M. Nat. Genet. (2002) [Pubmed]
  2. Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Bonawitz, N.D., Clayton, D.A., Shadel, G.S. Mol. Cell (2006) [Pubmed]
  3. Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin. Kravchenko, J.E., Rogozin, I.B., Koonin, E.V., Chumakov, P.M. Nature (2005) [Pubmed]
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