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Gene Review:

BW52 - Body weight QTL 52

Homo sapiens

Tanabe, T. et al., Isohisa, I. et al., Oyanagi, H. et al.

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Disease relevance of BW52

A 25-year-old Japanese woman had both ulcerative colitis and Takayasu's disease and was positive for HLA-A24, BW52, and DR2 [1].
These data indicate that a haplotype composed of A9, BW52, MT1 and DR2 is common in patients with aortitis syndrome and suggest that a genetic factor plays an important role on the pathogenesis of the disease [2].

High impact information on BW52

A survey of the homozygote of BW52 revealed 6 of 75 patients with BW52; however, statistically speaking, this rate did not differ from the expected one [3].

References

Ulcerative colitis associated with Takayasu's disease. Oyanagi, H., Ishihata, R., Ishikawa, H., Suzuki, S., Kondo, Y., Miyata, M., Obara, K., Nishimaki, T., Kasukawa, R., Tanno, Y. Intern. Med. (1994) [Pubmed]
Pathogenesis and surgical treatment of aortitis syndrome. Tanabe, T., Yokota, A., Yasuda, K. Jpn. Circ. J. (1982) [Pubmed]
Hereditary factors in Takayasu's disease. Isohisa, I., Numano, F., Maezawa, H., Sasazuki, T. Angiology. (1982) [Pubmed]

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