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MeSH Review


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Disease relevance of Aortitis


High impact information on Aortitis


Chemical compound and disease context of Aortitis

  • Regression of the left main trunk lesion by steroid administration in Takayasu's aortitis [10].
  • A 35 mg daily dose of prednisolone for aortitis syndrome was initiated, and the dose was gradually reduced [11].
  • Chronic aortitis following furosemide therapy [12].
  • Indium-111 labelled leucocyte uptake in aortitis [13].
  • A 39-year-old woman with primary myxedema, who had the potent activities of thyrotropin-binding inhibitory immunoglobulins (TBII) and thyroid-stimulation blocking antibodies (TSBAb), developed aortitis syndrome about 6 months after the initiation of L-thyroxine (L-T4) supplementation [11].

Biological context of Aortitis

  • These data indicate that a haplotype composed of A9, BW52, MT1 and DR2 is common in patients with aortitis syndrome and suggest that a genetic factor plays an important role on the pathogenesis of the disease [14].

Anatomical context of Aortitis

  • In the current study, we investigated the calcific degeneration of bioprosthetic aortic valves in patients who had been given steroid treatment for aortitis in order to evaluate the immune response to glutaraldehyde-preserved bioprostheses [15].
  • OBJECTIVES: The aim of this study was to determine the clinical and angiographic predictors of left ventricular systolic dysfunction (LVSD) from a relatively large and angiographically characterized Takayasu's or Giant Cell aortitis (TA/GCA) population [16].
  • CONCLUSIONS: In TA/GCA aortitis, LVSD is associated with involvement of the aortic arch and with the greater extent of aortic involvement [16].
  • These results suggest that there are intrinsic qualitative abnormalities in the T cells that produce IL-2 in aortitis syndrome [17].
  • Bone marrow cell transplants from IL-1Ra(-/-) mice also induced aortitis in irradiated wild-type recipient mice [18].

Gene context of Aortitis

  • Furthermore, tumor necrosis factor (TNF)-alpha deficiency completely suppressed the development of aortitis in IL-1Ra(-/-) mice, whereas IL-6 deficiency did not affect pathology [18].
  • Involvement of tumor necrosis factor-alpha in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice [18].
  • The HLA-A, B, DR and MB antigens were investigated in patients suffering from Takayasu disease (Aortitis syndrome) [19].
  • The active aortitis syndrome group produced significantly more interleukin-1 beta (IL-1 beta) than the inactive group [17].
  • CONCLUSIONS: These observations suggest that IL-1Ra deficiency in T cells activates them excessively, resulting in the development of aortitis in IL-1Ra(-/-) mice in a TNF-alpha-dependent manner [18].

Analytical, diagnostic and therapeutic context of Aortitis


  1. The role of the laboratory in the planned use of cefoperazone for the treatment of difficult Pseudomonas infections. McDonald, M., Miles, H., Carson, M. Drugs (1981) [Pubmed]
  2. Exercise thallium scintigraphy in aortitis syndrome (Takayasu's arteritis). Nishimura, T., Matsuo, T., Uehara, T., Hayashida, K., Kozuka, T., Nakayama, R. European journal of nuclear medicine. (1990) [Pubmed]
  3. Mycotic aneurysms of the aorta caused by infection with Pasteurella multocida. Balestra, B. Clin. Infect. Dis. (2000) [Pubmed]
  4. Paracoccidioidomycosis: case report and review. Manns, B.J., Baylis, B.W., Urbanski, S.J., Gibb, A.P., Rabin, H.R. Clin. Infect. Dis. (1996) [Pubmed]
  5. Rheumatoid arthritis with rheumatoid heart disease and granulomatous aortitis. Reimer, K.A., Rodgers, R.F., Oyasu, R. JAMA (1976) [Pubmed]
  6. Rheumatoid aortitis: a rarely recognized but clinically significant entity. Gravallese, E.M., Corson, J.M., Coblyn, J.S., Pinkus, G.S., Weinblatt, M.E. Medicine (Baltimore) (1989) [Pubmed]
  7. Diagnosis and follow up of aortitis in the elderly. Scheel, A.K., Meller, J., Vosshenrich, R., Kohlhoff, E., Siefker, U., Müller, G.A., Strutz, F. Ann. Rheum. Dis. (2004) [Pubmed]
  8. "Tree-barking" of the ascending aorta. Syphilis or systemic lupus erythematosus? MacLeod, C.B., Johnson, D., Frable, W.J. Am. J. Clin. Pathol. (1992) [Pubmed]
  9. Takayasu arteritis: diagnosis with MR imaging and MR angiography in acute and chronic active stages. Choe, Y.H., Kim, D.K., Koh, E.M., Do, Y.S., Lee, W.R. Journal of magnetic resonance imaging : JMRI. (1999) [Pubmed]
  10. Regression of the left main trunk lesion by steroid administration in Takayasu's aortitis. Iga, K., Gohma, I., Hori, K. Chest (1991) [Pubmed]
  11. Disappearance of thyroid-stimulation blocking antibody by glucocorticoid therapy in a patient with primary myxedema who developed aortitis syndrome during L-thyroxine supplementation. Shigemasa, C., Kouchi, T., Taniguchi, S., Mitani, Y., Mashiba, H. J. Endocrinol. Invest. (1990) [Pubmed]
  12. Chronic aortitis following furosemide therapy. Sommers, S.C., Higgins, T.E., Kimelblatt, B.J. Arch. Pathol. Lab. Med. (1984) [Pubmed]
  13. Indium-111 labelled leucocyte uptake in aortitis. Fink, A.M., Miles, K.A., Wraight, E.P. Clinical radiology. (1994) [Pubmed]
  14. Pathogenesis and surgical treatment of aortitis syndrome. Tanabe, T., Yokota, A., Yasuda, K. Jpn. Circ. J. (1982) [Pubmed]
  15. Calcific degeneration of bioprosthetic aortic valves in patients receiving steroid therapy. Eishi, K., Ishibashi-Ueda, H., Nakano, K., Kosakai, Y., Sasako, Y., Kobayashi, J., Yutani, C. J. Heart Valve Dis. (1996) [Pubmed]
  16. Predictors of left ventricular dysfunction in patients with Takayasu's or giant cell aortitis. Pfizenmaier, D.H., Al Atawi, F.O., Castillo, Y., Chandrasekaran, K., Cooper, L.T. Clinical and experimental rheumatology. (2004) [Pubmed]
  17. Cellular immunocompetence in aortitis syndrome. Hosotani, A., Uchida, H., Teramoto, S. Acta Med. Okayama (1993) [Pubmed]
  18. Involvement of tumor necrosis factor-alpha in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice. Matsuki, T., Isoda, K., Horai, R., Nakajima, A., Aizawa, Y., Suzuki, K., Ohsuzu, F., Iwakura, Y. Circulation (2005) [Pubmed]
  19. HLA-linked susceptibility gene of Takayasu Disease. Moriuchi, J., Wakisaka, A., Aizawa, M., Yasuda, K., Yokota, A., Tanabe, T., Itakura, K. Hum. Immunol. (1982) [Pubmed]
  20. Takayasu's aortitis with dissection in systemic lupus erythematosus. Kameyama, K., Kuramochi, S., Ueda, T., Kawada, S., Tominaga, N., Mimori, T., Hata, J. Scand. J. Rheumatol. (1999) [Pubmed]
  21. Lupus aortitis: a case report and review of the literature. Willett, W.F., Kahn, M.J., Gerber, M.A. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. (1996) [Pubmed]
  22. Aortitis during intraarterial chemotherapy for cervical cancer. Tanaka, H., Kondo, E., Kawato, H., Kikukawa, T., Toyoda, N. Int. J. Clin. Oncol. (2002) [Pubmed]
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