Disease relevance of Aortitis

• A 73-year-old woman, who had recurrent pseudomonas septicaemia due to infected cardiac pacing wires (that could not be removed), was managed with long term daily intramuscular cefoperazone, and a 31-year-old woman with pseudomonas aortitis was treated with long term intravenous cefoperazone [1].
• Twenty one cases of aortitis syndrome who experienced chest pain were examined using exercise thallium scintigraphy [2].
• We treated Pasteurella aortitis medically with ciprofloxacin, and the patient has had long-term survival [3].
• Exercise thallium scintigraphy in aortitis syndrome (Takayasu's arteritis) [2].
• A previously well 59-year-old man presented with paracoccidioidomycosis, more than 15 years after leaving South America. He failed to respond to conventional therapies, first with oral itraconazole and then with amphotericin B plus sulfadiazine, and eventually died of recurrent arterial emboli possibly due to paracoccidioidomycotic aortitis [4].

High impact information on Aortitis

• Aortic insufficiency and aortitis are frequent complications of ankylosing spondylitis but are considered rare in rheumatoid arthritis [5].
• Aortitis as a feature of rheumatoid arthritis is considered rare [6].
• METHODS: Eight patients with aortitis presenting with unspecific GCA-like symptoms were examined [7].
• A case of unsuspected classical aortitis with "tree-barking" of the ascending aorta in a young woman with systemic lupus erythematosus and inconclusive syphilitic serologic results is presented [8].
• Breath-hold contrast-enhanced three-dimensional MR angiography is very effective in noninvasive evaluation of luminal change of aortitis [9].

Chemical compound and disease context of Aortitis

• Regression of the left main trunk lesion by steroid administration in Takayasu's aortitis [10].
• A 35 mg daily dose of prednisolone for aortitis syndrome was initiated, and the dose was gradually reduced [11].
• Chronic aortitis following furosemide therapy [12].
• Indium-111 labelled leucocyte uptake in aortitis [13].
• A 39-year-old woman with primary myxedema, who had the potent activities of thyrotropin-binding inhibitory immunoglobulins (TBII) and thyroid-stimulation blocking antibodies (TSBAb), developed aortitis syndrome about 6 months after the initiation of L-thyroxine (L-T4) supplementation [11].

Biological context of Aortitis

• These data indicate that a haplotype composed of A9, BW52, MT1 and DR2 is common in patients with aortitis syndrome and suggest that a genetic factor plays an important role on the pathogenesis of the disease [14].

Anatomical context of Aortitis

• In the current study, we investigated the calcific degeneration of bioprosthetic aortic valves in patients who had been given steroid treatment for aortitis in order to evaluate the immune response to glutaraldehyde-preserved bioprostheses [15].
• OBJECTIVES: The aim of this study was to determine the clinical and angiographic predictors of left ventricular systolic dysfunction (LVSD) from a relatively large and angiographically characterized Takayasu's or Giant Cell aortitis (TA/GCA) population [16].
• CONCLUSIONS: In TA/GCA aortitis, LVSD is associated with involvement of the aortic arch and with the greater extent of aortic involvement [16].
• These results suggest that there are intrinsic qualitative abnormalities in the T cells that produce IL-2 in aortitis syndrome [17].
• Bone marrow cell transplants from IL-1Ra(-/-) mice also induced aortitis in irradiated wild-type recipient mice [18].

Gene context of Aortitis

• Furthermore, tumor necrosis factor (TNF)-alpha deficiency completely suppressed the development of aortitis in IL-1Ra(-/-) mice, whereas IL-6 deficiency did not affect pathology [18].
• Involvement of tumor necrosis factor-alpha in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice [18].
• The HLA-A, B, DR and MB antigens were investigated in patients suffering from Takayasu disease (Aortitis syndrome) [19].
• The active aortitis syndrome group produced significantly more interleukin-1 beta (IL-1 beta) than the inactive group [17].
• CONCLUSIONS: These observations suggest that IL-1Ra deficiency in T cells activates them excessively, resulting in the development of aortitis in IL-1Ra(-/-) mice in a TNF-alpha-dependent manner [18].

Analytical, diagnostic and therapeutic context of Aortitis

• Takayasu's aortitis with dissection in systemic lupus erythematosus [20].
• The aortitis was found to be immune complex mediated with deposition of IgG, C3, as well as fibrinogen in the wall of the aorta as shown by immunofluorescence [21].
• A 76-year-old woman with stage IIb cervical cancer with a bulky tumor experienced aortitis during continuous intraarterial cisplatin-based chemotherapy [22].

References