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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Foxo4  -  forkhead box O4

Mus musculus

Synonyms: Afx, Afx1, Afxh, Fkhr3, Fork head domain transcription factor AFX1, ...
 
 
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High impact information on Mllt7

  • On the other hand, both Foxo3a- and Foxo4-null mice were viable and grossly indistinguishable from their littermate controls, indicating dispensability of these two members of the Foxo transcription factor family for normal vascular development [1].
  • Accordingly, reduction of Foxo4 expression in SMCs by siRNA enhances myocardin activity and SMC differentiation [2].
  • We show that Foxo4 represses SMC differentiation by interacting with and inhibiting the activity of myocardin, a transcriptional coactivator of smooth muscle genes [2].
 

Anatomical context of Mllt7

 

Other interactions of Mllt7

  • We conclude that signal-dependent interaction of Foxo4 with myocardin couples extracellular signals with the transcriptional program for SMC differentiation [2].

References

  1. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Hosaka, T., Biggs, W.H., Tieu, D., Boyer, A.D., Varki, N.M., Cavenee, W.K., Arden, K.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Liu, Z.P., Wang, Z., Yanagisawa, H., Olson, E.N. Dev. Cell (2005) [Pubmed]
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