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Gene Review:

Myocd - myocardin

Rattus norvegicus

Synonyms: Mycd, Myocardin

Chen, J. et al., McDonald, O.G. et al., Wamhoff, B.R. et al., Morris, J.B. et al., Liu, Y. et al.

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High impact information on Myocd

We found that the promyogenic SRF coactivator myocardin increased SRF association with methylated histones and CArG box chromatin during activation of SMC gene expression [1].
Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression [2].
Thus, UTP inhibits transcriptional responses to phenylephrine only at cardiac-specific promoters, and this may involve the muscle-specific transcription enhancer, myocardin [3].
Transient transfection experiments with CMV-driven myocardin in both SMC and non-SMC reveal CArG-dependent transactivation of the SM-Calp promoter-enhancer [4].
To determine whether myocardin could activate an endogenous program of SMC differentiation, we stably transfected L6 myoblasts and assessed SMC marker expression and growth [4].

Anatomical context of Myocd

Myocardin: a component of a molecular switch for smooth muscle differentiation [4].

Associations of Myocd with chemical compounds

Both nifedipine and Y-27632 prevented the depolarization-induced increase in myocardin expression [5].

Regulatory relationships of Myocd

Moreover, short interfering RNA (siRNA) specific for myocardin attenuated depolarization-induced SMMHC/SM alpha-actin transcription [5].

References

Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. McDonald, O.G., Wamhoff, B.R., Hoofnagle, M.H., Owens, G.K. J. Clin. Invest. (2006) [Pubmed]
Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. Liu, Y., Sinha, S., McDonald, O.G., Shang, Y., Hoofnagle, M.H., Owens, G.K. J. Biol. Chem. (2005) [Pubmed]
UTP transactivates epidermal growth factor receptors and promotes cardiomyocyte hypertrophy despite inhibiting transcription of the hypertrophic marker gene, atrial natriuretic peptide. Morris, J.B., Pham, T.M., Kenney, B., Sheppard, K.E., Woodcock, E.A. J. Biol. Chem. (2004) [Pubmed]
Myocardin: a component of a molecular switch for smooth muscle differentiation. Chen, J., Kitchen, C.M., Streb, J.W., Miano, J.M. J. Mol. Cell. Cardiol. (2002) [Pubmed]
L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Wamhoff, B.R., Bowles, D.K., McDonald, O.G., Sinha, S., Somlyo, A.P., Somlyo, A.V., Owens, G.K. Circ. Res. (2004) [Pubmed]

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MYOCD	Bos taurus
MYOCD	Canis lupus familiaris
si:ch1073-80j9.1	Danio rerio
MYOCD	Gallus gallus
MYOCD	Homo sapiens
MYOCD	Macaca mulatta
Myocd	Mus musculus
MYOCD	Pan troglodytes
myocd	Xenopus (Silurana) tropicalis

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