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Gene Review

Pde3a  -  phosphodiesterase 3A, cGMP inhibited

Mus musculus

Synonyms: A930022O17Rik, C87899, CGI-PDE A, Cyclic GMP-inhibited phosphodiesterase A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A
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High impact information on Pde3a

  • The Pde3a(-/-) females were viable and ovulated a normal number of oocytes but were completely infertile, because ovulated oocytes were arrested at the germinal vesicle stage and, therefore, could not be fertilized [1].

Biological context of Pde3a

  • Pde3a(-/-) mice represent an in vivo model where meiotic maturation and ovulation are dissociated, which underscores inhibition of oocyte maturation as a potential strategy for contraception [1].

Associations of Pde3a with chemical compounds

  • Meiotic maturation in Pde3a(-/-) oocytes was restored by inhibiting protein kinase A (PKA) with adenosine-3',5'-cyclic monophosphorothioate, Rp-isomer (Rp-cAMPS) or by injection of protein kinase inhibitor peptide (PKI) or mRNA coding for phosphatase CDC25, which confirms that increased cAMP-PKA signaling is responsible for the meiotic blockade [1].


  1. Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. Masciarelli, S., Horner, K., Liu, C., Park, S.H., Hinckley, M., Hockman, S., Nedachi, T., Jin, C., Conti, M., Manganiello, V. J. Clin. Invest. (2004) [Pubmed]
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