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Gene Review

ATG16L1  -  autophagy related 16-like 1 (S. cerevisiae)

Homo sapiens

Synonyms: APG16-like 1, APG16L, ATG16A, ATG16L, Autophagy-related protein 16-1, ...
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Disease relevance of ATG16L1

  • ATG16L1 mRNA expression was not upregulated in CD and murine ileitis, and was less than threefold increased in cells stimulated with proinflammatory cytokines and TLR ligands [1].


  1. The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Glas, J., Konrad, A., Schmechel, S., Dambacher, J., Seiderer, J., Schroff, F., Wetzke, M., Roeske, D., Török, H.P., Tonenchi, L., Pfennig, S., Haller, D., Griga, T., Klein, W., Epplen, J.T., Folwaczny, C., Lohse, P., Göke, B., Ochsenkühn, T., Mussack, T., Folwaczny, M., Müller-Myhsok, B., Brand, S. Am. J. Gastroenterol. (2008) [Pubmed]
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