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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Ileitis


High impact information on Ileitis

  • Our results provide evidence that the primary defect conferring ileitis in SAMP mice originates from a nonhematopoietic source [6].
  • CONCLUSIONS: We have developed a novel intravascular US contrast agent targeting MAdCAM-1 that specifically detects and quantifies intestinal inflammation in experimental ileitis, providing the potential for a reliable, noninvasive means to diagnose and monitor disease in patients with IBD [7].
  • IL-4 blockade diminished IFN-gamma mRNA expression and significantly ameliorated the severity of established ileitis (P <.05) by decreasing the histologic indices for villous distortion and active inflammation [8].
  • Inhibition of the LTB4 biosynthetic enzyme 5-lipoxygenase inhibited toxin A-induced increases in ileal LTB4 levels and toxin A- but not LTB4-induced ileitis [4].
  • LTB4 also stimulated TRPV1-mediated substance P release and pretreatment with a specific substance P-receptor antagonist blocked LTB4-induced substance P action and ileitis [4].

Chemical compound and disease context of Ileitis

  • RESULTS: Indomethacin-induced ileitis in Lewis rats leads to specific reductions in ileal ASBT messenger RNA and protein levels, whereas c-jun and c-fos are induced [9].
  • Mesalamine in the treatment of mild to moderate active Crohn's ileitis: results of a randomized, multicenter trial [2].
  • Deconjugation of bile salts was assessed by measuring the rate of appearance of 14-CO2 in the breath after the administration of cholyl [1-14-C]glycine to patients with ileal dysfunction (ileitis or ileal resection), cholesterol cholelithiasis with or without cholecystectomy, and control subjects (healthy or with diarrhea) [10].
  • RESULTS: LTB4 caused ileitis similar to that caused by toxin A and antagonism of TRPV1 receptors but not LTB4 receptors inhibited LTB4-induced inflammation [4].
  • However, the mechanisms by which NOD2 mutations cause terminal ileitis are unknown, and NOD2 is expressed most highly by peripheral blood monocytes, which are distributed ubiquitously and readily respond to LPS via cell-surface receptors [11].
  • Ileitis also increased the number of colonic 5-hydroxytryptamine (5-HT)- and GLP-2-immunoreactive enteroendocrine cells [12].
  • Prophylactic treatment with the LPS scavenger polymyxin B ameliorated T gondii-induced ileitis [13].

Biological context of Ileitis


Anatomical context of Ileitis


Gene context of Ileitis


Analytical, diagnostic and therapeutic context of Ileitis


  1. Use of azathioprine or 6-mercaptopurine in the treatment of Crohn's disease. O'Brien, J.J., Bayless, T.M., Bayless, J.A. Gastroenterology (1991) [Pubmed]
  2. Mesalamine in the treatment of mild to moderate active Crohn's ileitis: results of a randomized, multicenter trial. Prantera, C., Cottone, M., Pallone, F., Annese, V., Franzè, A., Cerutti, R., Bianchi Porro, G. Gastroenterology (1999) [Pubmed]
  3. Coating of oral beclomethasone dipropionate capsules with cellulose acetate phthalate enhances delivery of topically active antiinflammatory drug to the terminal ileum. Levine, D.S., Raisys, V.A., Ainardi, V. Gastroenterology (1987) [Pubmed]
  4. The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats. McVey, D.C., Vigna, S.R. Gastroenterology (2005) [Pubmed]
  5. Yersinia enteritis and enterocolitis: gastroenterological aspects. Vantrappen, G., Ponette, E., Geboes, K., Bertrand, P. Gastroenterology (1977) [Pubmed]
  6. The primary defect in experimental ileitis originates from a nonhematopoietic source. Olson, T.S., Reuter, B.K., Scott, K.G., Morris, M.A., Wang, X.M., Hancock, L.N., Burcin, T.L., Cohn, S.M., Ernst, P.B., Cominelli, F., Meddings, J.B., Ley, K., Pizarro, T.T. J. Exp. Med. (2006) [Pubmed]
  7. Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease. Bachmann, C., Klibanov, A.L., Olson, T.S., Sonnenschein, J.R., Rivera-Nieves, J., Cominelli, F., Ley, K.F., Lindner, J.R., Pizarro, T.T. Gastroenterology (2006) [Pubmed]
  8. Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation. Bamias, G., Martin, C., Mishina, M., Ross, W.G., Rivera-Nieves, J., Marini, M., Cominelli, F. Gastroenterology (2005) [Pubmed]
  9. Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation. Chen, F., Ma, L., Sartor, R.B., Li, F., Xiong, H., Sun, A.Q., Shneider, B. Gastroenterology (2002) [Pubmed]
  10. Increased sensitivity of the cholylglycine breath test for detecting ileal dysfunction. Hepner, G.W. Gastroenterology (1975) [Pubmed]
  11. Crohn's disease and the NOD2 gene: a role for paneth cells. Lala, S., Ogura, Y., Osborne, C., Hor, S.Y., Bromfield, A., Davies, S., Ogunbiyi, O., Nuñez, G., Keshav, S. Gastroenterology (2003) [Pubmed]
  12. Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon. O'Hara, J.R., Lomax, A.E., Mawe, G.M., Sharkey, K.A. Gut (2007) [Pubmed]
  13. Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Heimesaat, M.M., Fischer, A., Jahn, H.K., Niebergall, J., Freudenberg, M., Blaut, M., Liesenfeld, O., Schumann, R.R., Göbel, U.B., Bereswill, S. Gut (2007) [Pubmed]
  14. TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis. Marini, M., Bamias, G., Rivera-Nieves, J., Moskaluk, C.A., Hoang, S.B., Ross, W.G., Pizarro, T.T., Cominelli, F. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. In vivo demonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1. Matsuzaki, K., Tsuzuki, Y., Matsunaga, H., Inoue, T., Miyazaki, J., Hokari, R., Okada, Y., Kawaguchi, A., Nagao, S., Itoh, K., Matsumoto, S., Miura, S. Clin. Exp. Immunol. (2005) [Pubmed]
  16. Kinetics of primary bile acids in patients with non-operated Crohn's disease. Rutgeerts, P., Ghoos, Y., Vantrappen, G. Eur. J. Clin. Invest. (1982) [Pubmed]
  17. Hla-B genotype in Japanese patients with Crohn's disease. Kinouchi, Y., Matsumoto, K., Negoro, K., Takagi, S., Takahashi, S., Hiwatashi, N., Shimosegawa, T. Dis. Colon Rectum (2003) [Pubmed]
  18. A novel triterpenoid induces transforming growth factor beta production by intraepithelial lymphocytes to prevent ileitis. Minns, L.A., Buzoni-Gatel, D., Ely, K.H., Rachinel, N., Luangsay, S., Kasper, L.H. Gastroenterology (2004) [Pubmed]
  19. Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. Singer, I.I., Kawka, D.W., Schloemann, S., Tessner, T., Riehl, T., Stenson, W.F. Gastroenterology (1998) [Pubmed]
  20. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Ogura, Y., Lala, S., Xin, W., Smith, E., Dowds, T.A., Chen, F.F., Zimmermann, E., Tretiakova, M., Cho, J.H., Hart, J., Greenson, J.K., Keshav, S., Nuñez, G. Gut (2003) [Pubmed]
  21. L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. Rivera-Nieves, J., Olson, T., Bamias, G., Bruce, A., Solga, M., Knight, R.F., Hoang, S., Cominelli, F., Ley, K. J. Immunol. (2005) [Pubmed]
  22. Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice. Takedatsu, H., Mitsuyama, K., Matsumoto, S., Handa, K., Suzuki, A., Takedatsu, H., Funabashi, H., Okabe, Y., Hara, T., Toyonaga, A., Sata, M. Eur. J. Immunol. (2004) [Pubmed]
  23. Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). McVey, D.C., Schmid, P.C., Schmid, H.H., Vigna, S.R. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  24. CD40/CD154 ligation is required for the development of acute ileitis following oral infection with an intracellular pathogen in mice. Li, W., Buzoni-Gatel, D., Debbabi, H., Hu, M.S., Mennechet, F.J., Durell, B.G., Noelle, R.J., Kasper, L.H. Gastroenterology (2002) [Pubmed]
  25. Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats. Barbier, M., Cherbut, C., Aubé, A.C., Blottière, H.M., Galmiche, J.P. Gut (1998) [Pubmed]
  26. Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease. D'Haens, G., Geboes, K., Ponette, E., Penninckx, F., Rutgeerts, P. Gastroenterology (1997) [Pubmed]
  27. Characterization of M cell development during indomethacin-induced ileitis in rats. Kucharzik, T., Lügering, A., Lügering, N., Rautenberg, K., Linnepe, M., Cichon, C., Reichelt, R., Stoll, R., Schmidt, M.A., Domschke, W. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  28. Regional ileitis (Crohn's disease). I. Kinetics of bile acid absorption in the perfused ileum. Krag, E., Krag, B. Scand. J. Gastroenterol. (1976) [Pubmed]
  29. Systemic effects of acute terminal ileitis on uninflamed gut aggravate bile acid malabsorption. Stelzner, M., Somasundaram, S., Khakberdiev, T. J. Surg. Res. (2001) [Pubmed]
  30. Tuberculous ileitis in a renal transplant recipient with familial Mediterranean fever: Gray-scale and power Doppler sonographic findings. Yilmaz, E., Balci, A., Sal, S., Cakmakci, H. Journal of clinical ultrasound : JCU. (2003) [Pubmed]
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