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Gene Review

USP40  -  ubiquitin specific peptidase 40

Homo sapiens

Synonyms: Deubiquitinating enzyme 40, FLJ10785, Ubiquitin carboxyl-terminal hydrolase 40, Ubiquitin thioesterase 40, Ubiquitin-specific-processing protease 40
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Disease relevance of USP40


High impact information on USP40

  • Both USP24 SNPs were significantly associated with disease risk (p = 0.0037 for rs1165222:T > C, p.Thr195ILe, and p = 0.037 for rs13312:C > G, a SNP in the 3'-untranslated region), and one marker, rs1048603:C > T, p.Arg1123Cys, in USP40 was significant from the chromosome 2 scan (p = 0.038) [1].


  1. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. Li, Y., Schrodi, S., Rowland, C., Tacey, K., Catanese, J., Grupe, A. Hum. Mutat. (2006) [Pubmed]
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