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Gene Review

USP24  -  ubiquitin specific peptidase 24

Homo sapiens

Synonyms: Deubiquitinating enzyme 24, KIAA1057, Ubiquitin carboxyl-terminal hydrolase 24, Ubiquitin thioesterase 24, Ubiquitin-specific-processing protease 24
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Disease relevance of USP24


High impact information on USP24

  • Immediately after purchase, four formulations (three sulfamethoxazole/trimethoprim and one sulphadoxine/pyrimethamine combination) failed the USP 24 dissolution test [2].
  • The purpose of the present study was to evaluate if the actual pharmacopeial conditions (with alterations introduced in the first supplement of USP 24) would also allow a good correlation between bioavailability and dissolution data [3].
  • Except for three metronidazole and one quinine formulations, dissolution tests performed after 6 months of storage under simulated tropical conditions showed that drug release remained within the USP 24 recommended values [2].
  • RESULTS: Drug content and drug release from all tested ciprofloxacin formulations were within USP-24 requirements and remained stable during storage at simulated tropical conditions [4].
  • However, seven formulations (three acetylsalicylic acid, two sulphadoxine/pyrimethamine and two paracetamol) failed to meet the USP 24 tolerance limits for dissolution [5].

Biological context of USP24

  • Twenty-one markers were significant in the expanded sample set (most significant allelic p-value: 0.0006 for rs287235:C > G on chromosome 1, and 0.005 for rs838552:T > C on chromosome 2), and six SNPs in USP24 remained significant after conservatively adjusting for testing 27 markers (pBonferroni = 0.017-0.049) [1].
  • In the initial phase of our study, we genotyped two putative functional SNPs in ubiquitin-specific protease 24 (USP24), a biological candidate gene within the chromosome 1 linkage region, and scanned the chromosome 2 linkage peak with 43 SNPs in a sample set of 224 PD cases and 186 matched controls [1].

Anatomical context of USP24

  • Drug release from the intercalation compound was performed in vitro in simulated intestinal fluid at pH 7.5 according to USP 24 and in a pH 7.0 solution designed to mimic the ionic conditions of the small intestine [6].

Associations of USP24 with chemical compounds

  • Ibuprofen tablets on the market in Japan and the USA were compared by manual- and automatic-dissolution tests according to USP24 criteria [7].
  • RESULTS AND DISCUSSION: At the time of purchase, the drug content of all the formulations was within the limits recommended by the USP 24, but after 6-month storage, the drug content of one sulfamethoxazole/trimethoprim and one quinine formulation were found to be substandard [2].
  • The rate of release of theophylline from the hot-melt extruded spherical pellets was characterized using USP 24 Apparatus 2 dissolution testing after initial pellet production and after 1 year storage in sealed HDPE containers at 25 degrees C/60% RH [8].
  • Only the reference product and one of the generic products studied met the 80% USP 24 specification for albendazole dissolved at 30 min, using USP Apparatus 2 [9].
  • Moreover, the release of nicotine from six production batches met the criteria of USP 24 [10].

Other interactions of USP24

  • Both USP24 SNPs were significantly associated with disease risk (p = 0.0037 for rs1165222:T > C, p.Thr195ILe, and p = 0.037 for rs13312:C > G, a SNP in the 3'-untranslated region), and one marker, rs1048603:C > T, p.Arg1123Cys, in USP40 was significant from the chromosome 2 scan (p = 0.038) [1].
  • Beginning in USP23 <788> (1) and continuing in USP 24 there is official recognition that the results of the nondestructive inspection for "visible" particles cannot be described in simple terms [11].

Analytical, diagnostic and therapeutic context of USP24

  • When the results were compared with those obtained by the official HPLC method (USP 24) the relative differences found were from 0.4 to 2.3%, with relative standard deviations below 1% [12].


  1. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. Li, Y., Schrodi, S., Rowland, C., Tacey, K., Catanese, J., Grupe, A. Hum. Mutat. (2006) [Pubmed]
  2. The quality of essential antimicrobial and antimalarial drugs marketed in Rwanda and Tanzania: influence of tropical storage conditions on in vitro dissolution. Kayumba, P.C., Risha, P.G., Shewiyo, D., Msami, A., Masuki, G., Ameye, D., Vergote, G., Ntawukuliryayo, J.D., Remon, J.P., Vervaet, C. Journal of clinical pharmacy and therapeutics. (2004) [Pubmed]
  3. Multiple level C in vitro/in vivo correlation of dissolution profiles of two L-thyroxine tablets with pharmacokinetics data obtained from patients treated for hypothyroidism. Volpato, N.M., Silva, R.L., Brito, A.P., Gonçalves, J.C., Vaisman, M., Noël, F. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2004) [Pubmed]
  4. Drug formulations intended for the global market should be tested for stability under tropical climatic conditions. Risha, P.G., Vervaet, C., Vergote, G., Bortel, L.V., Remon, J.P. Eur. J. Clin. Pharmacol. (2003) [Pubmed]
  5. In vitro evaluation of the quality of essential drugs on the Tanzanian market. Risha, P.G., Shewiyo, D., Msami, A., Masuki, G., Vergote, G., Vervaet, C., Remon, J.P. Trop. Med. Int. Health (2002) [Pubmed]
  6. Intercalation compounds of hydrotalcite-like anionic clays with anti-inflammatory agents, II: Uptake of diclofenac for a controlled release formulation. Ambrogi, V., Fardella, G., Grandolini, G., Perioli, L., Tiralti, M.C. AAPS PharmSciTech [electronic resource]. (2002) [Pubmed]
  7. International harmonization of generic drugs: in vitro dissolution tests for Japanese and American generic tablets. Otsuka, M., Tomita, H., Otsuka, K., Kamae, I., Jorgenson, J.A. Bio-medical materials and engineering. (2006) [Pubmed]
  8. Production of spherical pellets by a hot-melt extrusion and spheronization process. Young, C.R., Koleng, J.J., McGinity, J.W. International journal of pharmaceutics. (2002) [Pubmed]
  9. Comparison of dissolution profiles for albendazole tablets using USP apparatus 2 and 4. Hurtado y de la Peña, M., Vargas Alvarado, Y., Domínguez-Ramírez, A.M., Cortés Arroyo, A.R. Drug development and industrial pharmacy. (2003) [Pubmed]
  10. Acrylic matrix type nicotine transdermal patches: in vitro evaluations and batch-to-batch uniformity. Pongjanyakul, T., Prakongpan, S., Priprem, A. Drug development and industrial pharmacy. (2003) [Pubmed]
  11. Origin, result and measurement of USP "essentially free" inspection for visible contaminating particles. Knapp, J.Z. PDA journal of pharmaceutical science and technology / PDA. (2000) [Pubmed]
  12. Flow-injection spectrophotometric determination of paracetamol in tablets and oral solutions. Knochen, M., Giglio, J., Reis, B.F. Journal of pharmaceutical and biomedical analysis. (2003) [Pubmed]
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