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Gene Review

PSPC1  -  paraspeckle component 1

Homo sapiens

Synonyms: FLJ10955, PSP1, Paraspeckle component 1, Paraspeckle protein 1
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High impact information on PSPC1

  • Here we characterize paraspeckles, a subnuclear domain containing p54nrb and other RNA-binding proteins including PSP1, a protein with sequence similarity to p54nrb that acts as a marker for paraspeckles [1].
  • A stable cell line expressing YFP-PSP1 has been established and used to demonstrate that PSP1 interacts dynamically with nucleoli and paraspeckles in living cells [2].

Physical interactions of PSPC1

  • We show that PSP1 interacts in vivo with a subset of the total cellular pool of p54nrb [1].


  1. P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. Fox, A.H., Bond, C.S., Lamond, A.I. Mol. Biol. Cell (2005) [Pubmed]
  2. Paraspeckles: a novel nuclear domain. Fox, A.H., Lam, Y.W., Leung, A.K., Lyon, C.E., Andersen, J., Mann, M., Lamond, A.I. Curr. Biol. (2002) [Pubmed]
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