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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

OLAH  -  oleoyl-ACP hydrolase

Homo sapiens

Synonyms: AURA1, Augmented in rheumatoid arthritis 1, FLJ11106, Oleoyl-ACP hydrolase, S-acyl fatty acid synthase thioesterase, medium chain, ...
 
 
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High impact information on OLAH

  • Previous studies in our laboratory with rodents indicated that thioesterase II is expressed exclusively in mammary epithelial cells, an observation consistent with the physiologic role of the enzyme in milk fat synthesis [1].
  • Metabolic, enzymologic, and immunohistochemical techniques have been used to show that a human cell line of breast epithelial origin synthesized medium chain fatty acids via the ubiquitous fatty acid synthetase and a mammary-specific chain-terminating enzyme, thioesterase II [1].
 

Analytical, diagnostic and therapeutic context of OLAH

  • The presence of the two key enzymes characteristic of the medium-chain fatty acid biosynthetic pathway of nonruminants, fatty acid synthetase, and thioesterase II, was demonstrated both qualitatively, by immunohistochemistry, and quantitatively, by enzyme assay [2].

References

  1. Thioesterase II, a new marker enzyme for human cells of breast epithelial origin. Smith, S., Pasco, D., Pawlak, J., Thompson, B.J., Stampfer, M., Nandi, S. J. Natl. Cancer Inst. (1984) [Pubmed]
  2. Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution to the overall composition of human milk fat. Thompson, B.J., Smith, S. Pediatr. Res. (1985) [Pubmed]
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