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Gene Review

NOP10  -  NOP10 ribonucleoprotein

Homo sapiens

Synonyms: DKCB1, H/ACA ribonucleoprotein complex subunit 3, MGC70651, NOLA3, NOP10P, ...
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High impact information on NOLA3

  • Here, we describe the 2.1 A crystal structure of a specific complex of three archaeal H/ACA proteins, Cbf5, Nop10, and Gar1 [1].
  • NOP10 associates with NAP57 as a prerequisite for NHP2 binding [2].
  • Immunofluorescence microscopy experiments showed that hGAR1, hNOP10, and hNHP2 are localized in the dense fibrillar component of the nucleolus and in Cajal (coiled) bodies [3].


  1. Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita. Rashid, R., Liang, B., Baker, D.L., Youssef, O.A., He, Y., Phipps, K., Terns, R.M., Terns, M.P., Li, H. Mol. Cell (2006) [Pubmed]
  2. Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. Wang, C., Meier, U.T. EMBO J. (2004) [Pubmed]
  3. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Pogacić, V., Dragon, F., Filipowicz, W. Mol. Cell. Biol. (2000) [Pubmed]
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