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MeSH Review

Coiled Bodies

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Disease relevance of Coiled Bodies


Psychiatry related information on Coiled Bodies


High impact information on Coiled Bodies

  • The coiled body is a nuclear organelle that contains snRNPs involved in splicing, the non-snRNP splicing factor U2AF and the nucleolar protein fibrillarin [5].
  • Autoantibody to p80-coilin may be useful for the elucidation of the structure and function of the coiled body, and the availability of a cDNA sequence could be helpful in further studies to clarify the clinical significance of this autoantibody response [6].
  • Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin [6].
  • It was previously reported that in HeLa cells, SMN and SIP1 form discrete foci located next to Cajal (coiled) bodies, the so-called "gemini of coiled bodies" or "gems." An intriguing feature of gems is that they do not appear to contain snRNPs [7].
  • Taken together, Nopp140 appeared to shuttle between the nucleolus and the coiled bodies, and to chaperone the transport of other molecules [8].

Biological context of Coiled Bodies


Anatomical context of Coiled Bodies


Associations of Coiled Bodies with chemical compounds


Gene context of Coiled Bodies


Analytical, diagnostic and therapeutic context of Coiled Bodies


  1. A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution. Phelan, A., Carmo-Fonseca, M., McLaughlan, J., Lamond, A.I., Clements, J.B. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN. Young, P.J., Le, T.T., Dunckley, M., Nguyen, T.M., Burghes, A.H., Morris, G.E. Exp. Cell Res. (2001) [Pubmed]
  3. The behavior of the coiled body in cells infected with adenovirus in vitro. Rodrigues, S.H., Silva, N.P., Delício, L.R., Granato, C., Andrade, L.E. Mol. Biol. Rep. (1996) [Pubmed]
  4. Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons. Tolnay, M., Spillantini, M.G., Goedert, M., Ulrich, J., Langui, D., Probst, A. Acta Neuropathol. (1997) [Pubmed]
  5. The coiled body. Lamond, A.I., Carmo-Fonseca, M. Trends Cell Biol. (1993) [Pubmed]
  6. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. Andrade, L.E., Chan, E.K., Raska, I., Peebles, C.L., Roos, G., Tan, E.M. J. Exp. Med. (1991) [Pubmed]
  7. The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body. Carvalho, T., Almeida, F., Calapez, A., Lafarga, M., Berciano, M.T., Carmo-Fonseca, M. J. Cell Biol. (1999) [Pubmed]
  8. Nopp140 functions as a molecular link between the nucleolus and the coiled bodies. Isaac, C., Yang, Y., Meier, U.T. J. Cell Biol. (1998) [Pubmed]
  9. Microinjection of anti-coilin antibodies affects the structure of coiled bodies. Almeida, F., Saffrich, R., Ansorge, W., Carmo-Fonseca, M. J. Cell Biol. (1998) [Pubmed]
  10. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic nuclear structure. Carmo-Fonseca, M., Ferreira, J., Lamond, A.I. J. Cell Biol. (1993) [Pubmed]
  11. Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei. Ferreira, J.A., Carmo-Fonseca, M., Lamond, A.I. J. Cell Biol. (1994) [Pubmed]
  12. Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus. Bohmann, K., Ferreira, J.A., Lamond, A.I. J. Cell Biol. (1995) [Pubmed]
  13. The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies. Jordan, P., Cunha, C., Carmo-Fonseca, M. Mol. Biol. Cell (1997) [Pubmed]
  14. The biogenesis of the coiled body during early mouse development. Ferreira, J., Carmo-Fonseca, M. Development (1995) [Pubmed]
  15. Interaction between neuronal intranuclear inclusions and promyelocytic leukemia protein nuclear and coiled bodies in CAG repeat diseases. Yamada, M., Sato, T., Shimohata, T., Hayashi, S., Igarashi, S., Tsuji, S., Takahashi, H. Am. J. Pathol. (2001) [Pubmed]
  16. Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts. Frey, M.R., Bailey, A.D., Weiner, A.M., Matera, A.G. Curr. Biol. (1999) [Pubmed]
  17. The organization of ribosomal RNA processing correlates with the distribution of nucleolar snRNAs. Beven, A.F., Lee, R., Razaz, M., Leader, D.J., Brown, J.W., Shaw, P.J. J. Cell. Sci. (1996) [Pubmed]
  18. Prenucleolar bodies contain coilin and are assembled in Xenopus egg extract depleted of specific nucleolar proteins and U3 RNA. Bell, P., Scheer, U. J. Cell. Sci. (1997) [Pubmed]
  19. A novel nuclear structure containing the survival of motor neurons protein. Liu, Q., Dreyfuss, G. EMBO J. (1996) [Pubmed]
  20. Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies. Carmo-Fonseca, M., Pepperkok, R., Carvalho, M.T., Lamond, A.I. J. Cell Biol. (1992) [Pubmed]
  21. Coiled body heterogeneity induced by G(1) arrest with amiloride + bumetanide. Alliegro, M.C. Exp. Cell Res. (2002) [Pubmed]
  22. Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus. Lyon, C.E., Bohmann, K., Sleeman, J., Lamond, A.I. Exp. Cell Res. (1997) [Pubmed]
  23. The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. Schul, W., Groenhout, B., Koberna, K., Takagaki, Y., Jenny, A., Manders, E.M., Raska, I., van Driel, R., de Jong, L. EMBO J. (1996) [Pubmed]
  24. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Pogacić, V., Dragon, F., Filipowicz, W. Mol. Cell. Biol. (2000) [Pubmed]
  25. Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies. Liu, J., Hebert, M.D., Ye, Y., Templeton, D.J., Kung, H., Matera, A.G. J. Cell. Sci. (2000) [Pubmed]
  26. Tau phosphorylation and kinase activation in familial tauopathy linked to deln296 mutation. Ferrer, I., Pastor, P., Rey, M.J., Muñoz, E., Puig, B., Pastor, E., Oliva, R., Tolosa, E. Neuropathol. Appl. Neurobiol. (2003) [Pubmed]
  27. Coiled bodies without coilin. Bauer, D.W., Gall, J.G. Mol. Biol. Cell (1997) [Pubmed]
  28. Coiled bodies and U2 snRNA genes adjacent to coiled bodies are enriched in factors required for snRNA transcription. Schul, W., van Driel, R., de Jong, L. Mol. Biol. Cell (1998) [Pubmed]
  29. Nucleolar evolution and coiled bodies during meiotic prophase in Olea europaea: differential localization of nucleic acids. Olmedilla, A., de Dios Alché, J., Rodríguez-García, M.I. Eur. J. Cell Biol. (1997) [Pubmed]
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