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Gene Review:

BCAS4 - breast carcinoma amplified sequence 4

Homo sapiens

Synonyms: Breast carcinoma-amplified sequence 4, CNOL, FLJ20495

Bärlund, M. et al.

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Disease relevance of BCAS4

In conclusion, our results indicate that these novel genes, BCAS3 at 17q23 and BCAS4 at 20q13.2, undergo amplification, overexpression, and fusion in breast cancer and therefore may have a role in the frequent chromosomal alterations affecting these two loci [1].

High impact information on BCAS4

The BCAS4-BCAS3 fusion transcript was detected only in MCF7 cells, but the BCAS4 gene was also overexpressed in nine of 13 breast cancer cell lines [1].
Here we cloned two novel genes, breast carcinoma amplified sequence 3 (BCAS3) and 4 (BCAS4), from the two most common amplification sites in breast cancer, 17q23 and 20q13 [1].

Other interactions of BCAS4

Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer [1].

References

Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. Bärlund, M., Monni, O., Weaver, J.D., Kauraniemi, P., Sauter, G., Heiskanen, M., Kallioniemi, O.P., Kallioniemi, A. Genes Chromosomes Cancer (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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