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Gene Review

BCAS3  -  breast carcinoma amplified sequence 3

Homo sapiens

Synonyms: FLJ20128, GAOB1, MAAB
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Disease relevance of BCAS3


High impact information on BCAS3

  • We identified BCAS3 as a MTA1 chromatin target in a functional genomic screen [3].
  • Furthermore, we discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase II complex to the BCAS3 enhancer sequence [3].
  • Similar chimeric transcripts encoding portions of the MET oncogene and the BCAS3 gene also were overexpressed in EAs, suggesting that L1-5'ASP activation may occur at a broad level in primary EAs [4].
  • The BCAS4-BCAS3 fusion transcript was detected only in MCF7 cells, but the BCAS4 gene was also overexpressed in nine of 13 breast cancer cell lines [1].
  • Here, we report that BCAS3 overexpression in hormone receptor-positive premenopausal breast cancer seemed to be associated with impaired responses to tamoxifen [5].

Other interactions of BCAS3


  1. Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. Bärlund, M., Monni, O., Weaver, J.D., Kauraniemi, P., Sauter, G., Heiskanen, M., Kallioniemi, O.P., Kallioniemi, A. Genes Chromosomes Cancer (2002) [Pubmed]
  2. Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis. Siva, K., Inamdar, M.S. Gene Expr. Patterns (2006) [Pubmed]
  3. MTA1, a transcriptional activator of breast cancer amplified sequence 3. Gururaj, A.E., Singh, R.R., Rayala, S.K., Holm, C., den Hollander, P., Zhang, H., Balasenthil, S., Talukder, A.H., Landberg, G., Kumar, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma. Lin, L., Wang, Z., Prescott, M.S., van Dekken, H., Thomas, D.G., Giordano, T.J., Chang, A.C., Orringer, M.B., Gruber, S.B., Moran, J.V., Glover, T.W., Beer, D.G. Genes Chromosomes Cancer (2006) [Pubmed]
  5. Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Gururaj, A.E., Holm, C., Landberg, G., Kumar, R. Cell Cycle (2006) [Pubmed]
  6. Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1). Gururaj, A.E., Peng, S., Vadlamudi, R.K., Kumar, R. Mol. Endocrinol. (2007) [Pubmed]
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