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Gene Review

MBNL3  -  muscleblind-like splicing regulator 3

Homo sapiens

Synonyms: CHCR, Cys3His CCG1-required protein, FLJ11316, MBLX, MBLX39, ...
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High impact information on MBNL3

  • Two of the genes, MBNL and MBLL, are expressed in many adult tissues whereas MBXL is expressed predominantly in the placenta [1].
  • By suppression subtractive hybridization (SSH), we have cloned a novel human cDNA that encodes a Cys3His zinc finger protein named CHCR (Cys3His CCG1-Required) [2].

Other interactions of MBNL3

  • While MBNL1 seems to promote muscle differentiation, MBNL3 appears to function in an opposing manner inhibiting expression of muscle differentiation markers [3].


  1. Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells. Fardaei, M., Rogers, M.T., Thorpe, H.M., Larkin, K., Hamshere, M.G., Harper, P.S., Brook, J.D. Hum. Mol. Genet. (2002) [Pubmed]
  2. Inhibition of muscle differentiation by the novel muscleblind-related protein CHCR. Squillace, R.M., Chenault, D.M., Wang, E.H. Dev. Biol. (2002) [Pubmed]
  3. The Muscleblind family of proteins: an emerging class of regulators of developmentally programmed alternative splicing. Pascual, M., Vicente, M., Monferrer, L., Artero, R. Differentiation (2006) [Pubmed]
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