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Gene Review

mbl  -  CG33197 gene product from transcript...

Drosophila melanogaster

Synonyms: BG01127, CG10941, CG14477, CG33197, Dmel\CG33197, ...
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Disease relevance of mbl


High impact information on mbl


Biological context of mbl

  • Functional analysis of mbl, the observation that it also dominantly suppresses the sE-Jun(Asp) gain-of-function phenotype and the phenotypic similarity to mutants in the photoreceptor-specific glass gene suggest that mbl is a general factor required for photoreceptor differentiation [3].
  • On the other hand, the use of distantly located DNA probes in the mbl gene allowed us to orientate the transcription unit in the chromosome [5].
  • RT-PCRs with exon-specific primers downstream of exon 2 were unable to amplify products other than those expected from canonical mbl isoforms, thus indicating that no other exons were efficiently spliced downstream of exon 2 [6].
  • In this review, we focus on the Muscleblind family of tissue-specific alternative splicing regulators [7].
  • Muscleblind proteins bind pre-mRNA through an evolutionarily conserved tandem CCCH zinc finger domain [7].

Anatomical context of mbl

  • Analysis of clones mutant for mbl during eye development shows that it is autonomously required for photoreceptor differentiation [3].


  1. Myotonic dystrophy associated expanded CUG repeat muscleblind positive ribonuclear foci are not toxic to Drosophila. Houseley, J.M., Wang, Z., Brock, G.J., Soloway, J., Artero, R., Perez-Alonso, M., O'Dell, K.M., Monckton, D.G. Hum. Mol. Genet. (2005) [Pubmed]
  2. Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy. Miller, J.W., Urbinati, C.R., Teng-Umnuay, P., Stenberg, M.G., Byrne, B.J., Thornton, C.A., Swanson, M.S. EMBO J. (2000) [Pubmed]
  3. muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins. Begemann, G., Paricio, N., Artero, R., Kiss, I., Pérez-Alonso, M., Mlodzik, M. Development (1997) [Pubmed]
  4. The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2. Artero, R., Prokop, A., Paricio, N., Begemann, G., Pueyo, I., Mlodzik, M., Perez-Alonso, M., Baylies, M.K. Dev. Biol. (1998) [Pubmed]
  5. Electron microscopic in situ hybridization of digoxigenin-dUTP-labelled DNA probes with Drosophila melanogaster polytene chromosomes. Semeshin, V.F., Artero, R., Perez-Alonso, M., Shloma, V.V. Chromosome Res. (1998) [Pubmed]
  6. Noncanonical RNAs from transcripts of the Drosophila muscleblind gene. Houseley, J.M., Garcia-Casado, Z., Pascual, M., Paricio, N., O'Dell, K.M., Monckton, D.G., Artero, R.D. J. Hered. (2006) [Pubmed]
  7. The Muscleblind family of proteins: an emerging class of regulators of developmentally programmed alternative splicing. Pascual, M., Vicente, M., Monferrer, L., Artero, R. Differentiation (2006) [Pubmed]
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