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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MAPK4  -  mitogen-activated protein kinase 4

Homo sapiens

Synonyms: ERK-4, ERK4, Erk3-related, Erk4, Extracellular signal-regulated kinase 4, ...
 
 
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High impact information on MAPK4

  • Binding of ERK4 to MK5 is accompanied by phosphorylation and activation of MK5 [1].
  • We further show that the structure of MAPK6 is closely related to that of the gene encoding the homologous protein kinase p63(MAPK) (MAPK4), suggesting that the two genes arose by duplication [2].
  • This suggest that rMNK2 and ERK3 belong to a separate subfamily within the rat MAP-kinase multigene family [3].
  • The deduced amino acid sequence of rMNK2 indicated that it is the rat homolog of human p63(mapk), showing 94.5% identity. rMNK2 showed 77% homology with rat ERK3 and its human homolog p97(mapk), and 43% homology with both rat genes rMNK1(ERK1) and ERK2, within the kinase domain [3].
  • In contrast, a human Erk3-related protein kinase has been found to be expressed at a high level only in heart muscle and brain [4].
 

Biological context of MAPK4

  • Our analysis demonstrates that the ERK3 subfamily of MAP kinase genes is composed of two functional genes, MAPK6 and MAPK4, and several pseudogenes [2].
  • Interaction of ERK4 with MK5 leads to translocation of MK5 to the cytoplasm and to its activation by phosphorylation [5].

References

  1. Regulation of MAPK-activated Protein Kinase 5 Activity and Subcellular Localization by the Atypical MAPK ERK4/MAPK4. Aberg, E., Perander, M., Johansen, B., Julien, C., Meloche, S., Keyse, S.M., Seternes, O.M. J. Biol. Chem. (2006) [Pubmed]
  2. The protein kinase ERK3 is encoded by a single functional gene: genomic analysis of the ERK3 gene family. Turgeon, B., Lang, B.F., Meloche, S. Genomics (2002) [Pubmed]
  3. Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. García, J.I., Zalba, G., Detera-Wadleigh, S.D., de Miguel, C. Mamm. Genome (1996) [Pubmed]
  4. Transcriptional regulation by MAP kinases. Davis, R.J. Mol. Reprod. Dev. (1995) [Pubmed]
  5. Characterization of the Atypical MAPK ERK4 and Its Activation of the MAPK-activated Protein Kinase MK5. Kant, S., Schumacher, S., Singh, M.K., Kispert, A., Kotlyarov, A., Gaestel, M. J. Biol. Chem. (2006) [Pubmed]
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