Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

FMR3 - fragile X mental retardation associated 3

Homo sapiens

Santos-Rebouças, C.B. et al., Gécz, J.

Santos-Rebouças, Abdalla, Fullston, Campos, Pimentel, Gécz, Gécz,

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Psychiatry related information on FMR3

Lack of FMR3 expression in a male with non-syndromic mental retardation and a microdeletion immediately distal to FRAXE CCG repeat [1].

High impact information on FMR3

This is the first study showing missing expression in the FMR3 gene with normal FMR2 transcription leading to FRAXE mutation-likely phenotype [1].
Two genes, FMR2 and FMR3 (likely a non-coding RNA) are transcribed from the FRAXE CpG island in the opposite directions [1].
We have established a skin fibroblast cell line from this patient and tested expression of both FMR2 and FMR3 genes [1].

Biological context of FMR3

We have identified a novel gene, FMR3, originating from the FRAXE CpG island [2].

References

Lack of FMR3 expression in a male with non-syndromic mental retardation and a microdeletion immediately distal to FRAXE CCG repeat. Santos-Rebouças, C.B., Abdalla, C.B., Fullston, T., Campos, M., Pimentel, M.M., Gécz, J. Neurosci. Lett. (2006) [Pubmed]
FMR3 is a novel gene associated with FRAXE CpG island and transcriptionally silent in FRAXE full mutations. Gécz, J. J. Med. Genet. (2000) [Pubmed]

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